Vincristine-induced peripheral neuropathy: a mini-review.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2020.10.004
Abstract: Vincristine (VCR), an alkaloid extracted from vinca, is often used in combination with other chemotherapeutic drugs to treat a variety of cancers, such as acute lymphoblastic leukaemia (ALL), malignant lymphoma, and neuroblastoma. However, VCR possesses… read more here.
Keywords: peripheral neuropathy; neuropathy mini; vincristine induced; induced peripheral ... See more keywords
Incidence of vincristine induced neurotoxicity in children with acute lymphoblastic leukemia and its correlation with nutritional deficiencies
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2019.1637981
Abstract: Abstract Injection vincristine is an important component of therapy for acute lymphoblastic leukemia (ALL). An important adverse effect of vincristine is neurotoxicity. The incidence of this adverse effect is well studied. The present was undertaken… read more here.
Keywords: vincristine induced; lymphoblastic leukemia; correlation; acute lymphoblastic ... See more keywords
Vincristine-induced neurotoxicity in pediatric patients with rhabdomyosarcoma: A retrospective analysis of clinical features and outcome
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DOI: 10.1080/08880018.2022.2047849
Abstract: Abstract Vincristine is an essential component of rhabdomyosarcoma treatment. However, it can cause motor neurotoxicity, necessitating dose reductions. We retrospectively reviewed the rates and patterns of vincristine-induced motor neuropathy in children treated for rhabdomyosarcoma, and… read more here.
Keywords: induced neurotoxicity; vincristine; vincristine induced; neurotoxicity pediatric ... See more keywords
Obesity as a Potential Risk Factor for Vincristine-induced Peripheral Neuropathy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001604
Abstract: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Vincristine is a core chemotherapeutic agent for patients with ALL; unfortunately, ∼78% will develop vincristine-induced peripheral neuropathy (VIPN). VIPN can result in vincristine dose reductions… read more here.
Keywords: risk; induced peripheral; peripheral neuropathy; vipn ... See more keywords
Contribution of common and rare genetic variants in CEP72 on vincristine‐induced peripheral neuropathy in brain tumour patients
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15267
Abstract: Studies implicated a role for a genetic variant in CEP72 in vincristine‐induced peripheral neuropathy. This study aims to evaluate this association in a cohort of brain tumour patients, to perform a cross‐disease meta‐analysis and explore… read more here.
Keywords: vincristine induced; peripheral neuropathy; cep72 vincristine; brain tumour ... See more keywords
Nerve cross‐sectional area in vincristine‐induced polyneuropathy: A nerve ultrasound pilot study
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuroimaging"
DOI: 10.1111/jon.13255
Abstract: The role of high‐resolution nerve ultrasound (HRUS) in the diagnosis of chemotherapy‐induced polyneuropathy is unclear. The present prospective longitudinal controlled study evaluates the utility of HRUS in vincristine‐induced polyneuropathy (VIPN). read more here.
Keywords: induced polyneuropathy; nerve ultrasound; nerve; study ... See more keywords
Celastrol Ameliorates Vincristine-induced Neuropathic Pain by Inhibiting Spinal Astrocyte Hyperactivation-mediated Inflammation, Oxidative Stress, and Apoptosis.
Sign Up to like & getrecommendations! Published in 2025 at "Current neuropharmacology"
DOI: 10.2174/011570159x385690250509050208
Abstract: BACKGROUND Neurotoxicity is the severe adverse reaction induced by chemotherapy drugs, characterized by neuropathic pain. However, there is a notable lack of therapeutic drugs for chemotherapy-induced neuropathic pain (CINP). Celastrol, a naturally occurring terpenoid active… read more here.
Keywords: celastrol; pain; vincristine induced; neuropathic pain ... See more keywords
Minocycline Prevents the Development of Mechanical Allodynia in Mouse Models of Vincristine-Induced Peripheral Neuropathy
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00653
Abstract: Vincristine is an antineoplastic substance that is part of many chemotherapy regimens, used especially for the treatment of a variety of pediatric cancers including leukemias and brain tumors. Unfortunately, many vincristine-treated patients develop peripheral neuropathy,… read more here.
Keywords: treatment; peripheral neuropathy; vincristine induced; induced peripheral ... See more keywords
Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling
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DOI: 10.3389/fonc.2020.01274
Abstract: Combination therapies that display cancer-killing activities through either coexistent targeting of several cellular factors or more efficient suppression of a specific pathway are generally used in cancer treatment. Sildenafil, a specific phosphodiesterase type 5 (PDE5)… read more here.
Keywords: vincristine; vincristine induced; sildenafil; cancer ... See more keywords
Mechanisms Underlying Gastrodin Alleviating Vincristine-Induced Peripheral Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.744663
Abstract: Gastrodin (GAS) is the main bioactive ingredient of Gastrodia, a famous Chinese herbal medicine widely used as an analgesic, but the underlying analgesic mechanism is still unclear. In this study, we first observed the effects… read more here.
Keywords: vincristine induced; induced peripheral; neuropathic pain; gas ... See more keywords
Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy in Children with Cancer: A Systematic Review and Meta-Analysis
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DOI: 10.3390/cancers14030612
Abstract: Simple Summary Vincristine is a drug that is part of the treatment for many children with cancer. Its main side-effect is vincristine-induced peripheral neuropathy (VIPN), which often presents as tingling, pain, and lack of strength… read more here.
Keywords: vincristine; vincristine induced; peripheral neuropathy; vipn ... See more keywords