An assessment of the role of vinculin loss of function variants in inherited cardiomyopathy
Sign Up to like & getrecommendations! Published in 2020 at "Human Mutation"
DOI: 10.1002/humu.24061
Abstract: The ACMG/AMP variant classification framework was intended for highly penetrant Mendelian conditions. While it is appreciated that clinically relevant variants exhibit a wide spectrum of penetrance, accurately assessing and expressing the pathogenicity of variants with… read more here.
Keywords: vinculin; penetrance; loss function; function variants ... See more keywords
Anti-vinculin autoantibodies in systemic sclerosis: a step toward a novel biomarker?
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Rheumatology"
DOI: 10.1007/s10067-020-05533-2
Abstract: Systemic sclerosis (SSc) is an autoimmune systemic vasculopathy that leads to wide-spread organ fibrosis. Gastrointestinal (GI) involvement in SSc is common and often results in debilitating symptoms that can lead to malnutrition and in severe… read more here.
Keywords: vinculin; ssc; disease; anti vinculin ... See more keywords
Vinculin controls endothelial cell junction dynamics during vascular lumen formation.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110658
Abstract: Blood vessel morphogenesis is driven by coordinated endothelial cell behaviors. Active remodeling of cell-cell junctions promotes cellular plasticity while preserving vascular integrity. Here, we analyze the dynamics of endothelial adherens junctions during lumen formation in… read more here.
Keywords: junctional fingers; endothelial cell; vinculin; cell ... See more keywords
Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.02.020
Abstract: Vinculin, a mechanotransducer associated with both adherens junctions (AJs) and focal adhesions (FAs), plays a central role in force transmission through cell-cell and cell-substratum contacts. We generated the conditional knockout (cKO) of vinculin in murine… read more here.
Keywords: vinculin; quiescence; hair; adherens junctions ... See more keywords
Force-Dependent Interactions between Talin and Full-Length Vinculin.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c06223
Abstract: Talin and vinculin are part of a multicomponent system involved in mechanosensing in cell-matrix adhesions. Both exist in autoinhibited forms, and activation of vinculin requires binding to mechanically activated talin, yet how forces affect talin's… read more here.
Keywords: vinculin; force; dependent interactions; interactions talin ... See more keywords
Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49850-5
Abstract: Force transmission through adherens junctions (AJs) is crucial for multicellular organization, wound healing and tissue regeneration. Recent studies shed light on the molecular mechanisms of mechanotransduction at the AJs. However, the canonical model fails to… read more here.
Keywords: adherens junctions; vinculin; catenin; force transmission ... See more keywords
α–Catenin-dependent vinculin recruitment to adherens junctions is antagonistic to focal adhesions
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-02-0071
Abstract: Vinculin is a protein found in both focal adhesions (FAs) and adherens junctions (AJs) which regulates actin connectivity to these structures. Many studies have demonstrated that mechanical perturbations of cells result in enhanced recruitment of… read more here.
Keywords: vinculin; recruitment; vinculin recruitment; focal adhesions ... See more keywords
Förster resonance energy transfer efficiency of the vinculin tension sensor in cultured primary cortical neuronal growth cones
Sign Up to like & getrecommendations! Published in 2022 at "Neurophotonics"
DOI: 10.1117/1.nph.9.2.025002
Abstract: Abstract. Significance: Interaction of neurons with their extracellular environment and the mechanical forces at focal adhesions and synaptic junctions play important roles in neuronal development. Aim: To advance studies of mechanotransduction, we demonstrate the use… read more here.
Keywords: growth cones; fret efficiency; tension; vinculin ... See more keywords
Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin—talin/α-catenin linkages
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav2720
Abstract: Single-molecule manipulation reveals high mechanical stability of vinculin—talin and vinculin—α-catenin protein-protein interfaces. The vinculin-mediated mechanosensing requires establishment of stable mechanical linkages between vinculin to integrin at focal adhesions and to cadherins at adherens junctions through… read more here.
Keywords: high mechanical; vinculin; single molecule; catenin ... See more keywords
Vinculin forms a directionally asymmetric catch bond with F-actin
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aan2556
Abstract: Making the right catch Tension reveals cryptic vinculin-binding sites on α-catenin and talin at cadherin-based cell-cell and integrin-based cell-matrix adhesions, respectively. The enrichment of vinculin at cellular adhesions is thus an indicator of load-induced reinforcement… read more here.
Keywords: vinculin; actin; bond; force ... See more keywords
A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.158378
Abstract: The LAMA5 gene encodes laminin α5, an indispensable component of glomerular basement membrane and other types of basement membrane. A homozygous pathological variant in LAMA5 is known to cause a systemic developmental syndrome including glomerulopathy.… read more here.
Keywords: pulmonary defects; laminin; slowly progressive; heterozygous lama5 ... See more keywords