Expression of tabersonine 16‐hydroxylase and 16‐hydroxytabersonine‐O‐methyltransferase in Catharanthus roseus hairy roots
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26487
Abstract: The monoterpene indole alkaloids vindoline and catharanthine, which are exclusively synthesized in the medicinal plant Catharanthus roseus, are the two important precursors for the production of pharmaceutically important anti‐cancer medicines vinblastine and vincristine. Hairy root… read more here.
Keywords: hairy roots; vindoline; hydroxytabersonine; pathway ... See more keywords
Phenotypic, genetic and expression profiling of a vindoline-rich genotype of Catharanthus roseus
Sign Up to like & getrecommendations! Published in 2021 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2021.02.004
Abstract: Abstract Catharanthus roseus is known for its scarce and expensive anticancer bisindole alkaloids, vincristine and vinblastine, which are derived from the coupling of monomeric terpenoid indole alkaloids, catharanthine and vindoline. Vindoline represents the bottleneck in… read more here.
Keywords: expression; vindoline; rich genotype; vindoline rich ... See more keywords
Tris(4-bromophenyl)aminium Hexachloroantimonate-Mediated Intermolecular C(sp2)-C(sp3) Free Radical Coupling of Vindoline with β-Ketoesters and Related Compounds.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c10971
Abstract: A powerful tris(4-bromophenyl)aminium hexachloroantimonate (BAHA) mediated regioselective intermolecular coupling reaction of vindoline with a wide range of substrates that include β-ketoesters, β-diketones, β-ketoaldehydes, β-ketonitriles, β-ketolactones, β-ketolactams, β-cyanoesters, and malononitriles is detailed. The BAHA-promoted intermolecular sp3/sp2… read more here.
Keywords: reaction; ketoesters related; aminium hexachloroantimonate; vindoline ... See more keywords
Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02617-w
Abstract: Vindoline is a plant derived monoterpene indole alkaloid (MIA) with potential therapeutic applications and more importantly serves as the precursor to vinblastine and vincristine. To obtain a yeast strain for high yield production of vindoline… read more here.
Keywords: efficient production; production vindoline; vindoline; vindoline tabersonine ... See more keywords
GATA and Phytochrome Interacting Factor Transcription Factors Regulate Light-Induced Vindoline Biosynthesis in Catharanthus roseus1[OPEN]
Sign Up to like & getrecommendations! Published in 2019 at "Plant Physiology"
DOI: 10.1104/pp.19.00489
Abstract: A regulatory module consisting of Phytochrome Interacting Factor (PIF) and GATA transcription factors regulates light-induced vindoline biosynthesis in Catharanthus roseus seedlings. Catharanthus roseus is the exclusive source of an array of terpenoid indole alkaloids including… read more here.
Keywords: vindoline; phytochrome interacting; interacting factor; factor ... See more keywords
Synthesis and Cytotoxic Activity of New Vindoline Derivatives Coupled to Natural and Synthetic Pharmacophores
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DOI: 10.3390/molecules25041010
Abstract: New Vinca alkaloid derivatives were synthesized to improve the biological activity of the natural alkaloid vindoline. To this end, experiments were performed to link vindoline with various structural units, such as amino acids, a 1,2,3-triazole… read more here.
Keywords: activity new; vindoline; new vindoline; synthesis cytotoxic ... See more keywords
In Vitro Antidiabetic and Antioxidant Effects of Different Extracts of Catharanthus roseus and Its Indole Alkaloid, Vindoline
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25235546
Abstract: The Catharanthus roseus plant has been used traditionally to treat diabetes mellitus. Scientific evidence supporting the antidiabetic effects of this plant’s active ingredient-vindoline has not been fully evaluated. In this study, extracts of C. roseus… read more here.
Keywords: plant; catharanthus roseus; vindoline; antidiabetic antioxidant ... See more keywords