Combined treatment with pemetrexed and vinflunine in patients with metastatic urothelial cell carcinoma after prior platinum-containing chemotherapy – results of an exploratory phase I study
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DOI: 10.1007/s10637-017-0528-y
Abstract: SummaryVinflunine is to date the only registered agent for second-line treatment of metastatic urothelial cell carcinoma (UCC) in Europe. However, the effect is modest. Pemetrexed has demonstrated some single-agent activity in this disease entity. In… read more here.
Keywords: urothelial cell; cell carcinoma; treatment; vinflunine ... See more keywords
Vinflunine in Advanced Transitional Cell Cancer of the Urothelial Tract: A Potential Option for Maintenance Therapy? A Case Series
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DOI: 10.1159/000481098
Abstract: Introduction: Vinflunine is a microtubule inhibitor approved in Europe as second-line treatment of advanced transitional cell cancer of the urothelium (TCCU). The inability to continue with a first-line platinum-based regimen beyond 6 cycles suggested investigating… read more here.
Keywords: maintenance therapy; line; maintenance; treatment ... See more keywords
Genomic Landscape of Vinflunine Response in Metastatic Urothelial Cancer
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DOI: 10.3390/cancers14020378
Abstract: Simple Summary Few metastatic urothelial cancer patients achieve durable clinical benefit with vinflunine. Predictive biomarkers to help to identify better treatment strategies are extremely needed. The objective of this study was to identify molecular differences… read more here.
Keywords: metastatic urothelial; vinflunine; urothelial cancer; response ... See more keywords