PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine sensitization in breast cancer cell lines
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DOI: 10.1007/s10549-018-4888-6
Abstract: PurposePARP-3 is member of the PARP family of poly (ADP-ribose) polymerases involved in ADPribosylation. PARPs are involved in the basic mechanisms of DNA repair. PARP3, a critical player for efficient mitotic progression, is required for… read more here.
Keywords: parp3; vinorelbine; parp3 inhibitors; breast cancer ... See more keywords
Oral or intravenous vinorelbine plus capecitabine in heavily pretreated HER2 negative metastatic breast cancer; similar effect or quality of life?
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DOI: 10.1007/s10549-019-05220-0
Abstract: I want to congratulate Torres and their colleagues [1] in which they investigated evaluated the efficacy and safety of the Vinorelbine/Capecitabine doublet (VINOCAP) in heavily pretreated HER2 negative metastatic breast cancer (MBC) patients with vinorelbine… read more here.
Keywords: vinorelbine; heavily pretreated; breast cancer; her2 negative ... See more keywords
A randomized evaluation of vinorelbine versus gemcitabine chemotherapy mobilization of stem cells in myeloma patients
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DOI: 10.1038/s41409-020-0875-8
Abstract: Numerous studies have established bortezomib-based tripleinduction regimens followed by high-dose melphalan chemotherapy with autologous stem cell transplantation (ASCT) as first-line treatment in fit myeloma patients [1–3]. Cyclophosphamide with G-CSF or G-CSF alone are most frequently… read more here.
Keywords: cd34 mobilization; gemcitabine; vinorelbine; myeloma patients ... See more keywords
A Phase I/II study of the combination of lapatinib and oral vinorelbine in HER2-positive metastatic breast cancer
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DOI: 10.1093/jjco/hyx188
Abstract: Background The combination of lapatinib and oral vinorelbine for HER2 positive metastatic breast cancer (MBC) is convenient but with uncertain toxicity profiles. A Phase I/II study was designed to understand the tolerability and efficacy of… read more here.
Keywords: phase study; vinorelbine; her2 positive; oral vinorelbine ... See more keywords
Posterior reversible encephalopathy syndrome associated with the use of chemotherapeutic agents: a rare complication after treatment with vinorelbine
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DOI: 10.1136/bcr-2019-229319
Abstract: The posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome characterised by a combination of headache, encephalopathy, seizures and visual disturbances, associated with high-intensity abnormalities on T2-weighted images affecting subcortical white and grey matter of… read more here.
Keywords: encephalopathy syndrome; vinorelbine; posterior reversible; associated use ... See more keywords
Metronomic Chemotherapy with Vinorelbine Produces Clinical Benefit and Low Toxicity in Frail Elderly Patients Affected by Advanced Non-Small Cell Lung Cancer
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DOI: 10.1155/2018/6278403
Abstract: Background Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused… read more here.
Keywords: vinorelbine; lung cancer; elderly patients; non small ... See more keywords
Final results of RENO study: Randomized phase II of oral vinorelbine or etoposide with cisplatin and chemo-radiation in stage III NSCLC. SLCG 10/02.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e20521
Abstract: e20521Background: This study aims to compare efficacy and safety of two widely used combinations of cisplatin (P) in this setting: as etoposide (E) and vinorelbine. This last, in its oral formulati... read more here.
Keywords: vinorelbine; final results; randomized phase; results reno ... See more keywords
Chitosan-Coated Liposomes: The Strategy to Reduce Intestinal Toxicity and Improve Bioavailability of Oral Vinorelbine
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DOI: 10.1208/s12249-022-02308-7
Abstract: In recent years, the oral administration of vinorelbine has gradually replaced intravenous administration in the treatment of several types of tumors. Even though the risk of phlebitis is avoided with oral administration, oral vinorelbine is… read more here.
Keywords: chitosan coated; administration; coated liposomes; vinorelbine ... See more keywords
Can Previous Chemotherapy Affect the Outcome of Nivolumab Treatment in Non-small Cell Lung Cancer?
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DOI: 10.21873/anticanres.15677
Abstract: Aim: This study compared the results of nivolumab treatment in patients with pulmonary adenocarcinomas based upon previous chemotherapeutic regimens. Patients and Methods: The data source for this retrospective study was the Czech VILP registry of… read more here.
Keywords: cisplatin pemetrexed; vinorelbine; treatment; line ... See more keywords
Metronomic Oral Vinorelbine: An Alternative Schedule in Elderly and Patients PS2 With Local/Advanced and Metastatic NSCLC Not Oncogene-addicted
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DOI: 10.21873/invivo.12088
Abstract: Background: The MILES and ELVIS studies showed that vinorelbine is one of the best options for elderly patients with advanced non-small-cell-lung cancer (NSCLC). Oral vinorelbine at standard schedule (60-80 mg/m2/weekly) has good activity in terms… read more here.
Keywords: advanced metastatic; oral vinorelbine; vinorelbine; metronomic oral ... See more keywords
Systematic Analysis of Genetic and Pathway Determinants of Eribulin Sensitivity across 100 Human Cancer Cell Lines from the Cancer Cell Line Encyclopedia (CCLE)
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DOI: 10.3390/cancers14184532
Abstract: Simple Summary Despite decades of clinical use and detailed understandings of their mechanisms of action, clinically useful predictive biomarkers for approved microtubule targeting agents such as eribulin, paclitaxel and vinorelbine have eluded development. Our results… read more here.
Keywords: cell; cell line; vinorelbine; cancer cell ... See more keywords