Renoprotective effect of vinpocetine against ischemia/reperfusion injury: Modulation of NADPH oxidase/Nrf2, IKKβ/NF‐κB p65, and cleaved caspase‐3 expressions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23046
Abstract: Ischemia/reperfusion injury (IRI) during kidney transplantation is a serious clinical problem with a high mortality rate and a lack of therapy. Therefore, there is a need to improve the ability of the kidney to tolerate… read more here.
Keywords: ikk p65; effect vinpocetine; nadph oxidase; vinpocetine ... See more keywords
Early ethanol exposure and vinpocetine treatment alter learning‐ and memory‐related proteins in the rat hippocampus and prefrontal cortex
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23894
Abstract: This study investigates the effects of early exposure to ethanol on cognitive function and neural plasticity‐related proteins in the rat brain. Sprague‐Dawley rats were administered 12% ethanol solution (4 g/kg/day i.p.) or saline from P4 to… read more here.
Keywords: early ethanol; vinpocetine; ethanol exposure; related proteins ... See more keywords
Vinpocetine Attenuates Pathological Cardiac Remodeling by Inhibiting Cardiac Hypertrophy and Fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-017-6719-0
Abstract: PurposePathological cardiac remodeling, characterized by cardiac hypertrophy and fibrosis, is a pathological feature of many cardiac disorders that leads to heart failure and cardiac arrest. Vinpocetine, a derivative of the alkaloid vincamine, has been used… read more here.
Keywords: cardiac hypertrophy; vinpocetine; fibrosis; cardiac remodeling ... See more keywords
The influence of vinpocetine alone or in combination with Epigallocatechin-3-gallate, Coenzyme COQ10, Vitamin E and Selenium as a potential neuroprotective combination against aluminium-induced Alzheimer's disease in Wistar Albino Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of gerontology and geriatrics"
DOI: 10.1016/j.archger.2021.104557
Abstract: Alzheimer's disease (AD) is one of such diseases that represent the most prominent cause of dementia in elderly people. To explore the possible neuroprotective effect as well as mechanism of action of Vinpocetine either alone… read more here.
Keywords: combination; alone combination; vinpocetine; alzheimer disease ... See more keywords
Vinpocetine enhances cisplatin sensitivity of non-small cell lung cancer cells by reducing the nuclear factor erythroid 2-related factor 2 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Investigative Medicine"
DOI: 10.1136/jim-2022-002369
Abstract: Vinpocetine exerts pharmacological effects against cardiovascular diseases, while few studies focused on its roles in cancer. The present study investigated the roles of vinpocetine in non-small cell lung cancer (NSCLC) and its relationship with cisplatin… read more here.
Keywords: cell; non small; vinpocetine; small cell ... See more keywords
Design, Characterization, and Application of a pH-Triggered In Situ Gel for Ocular Delivery of Vinpocetine.
Sign Up to like & getrecommendations! Published in 2020 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-020-01791-0
Abstract: We developed a pH-triggered in situ gel (ISG) for ocular delivery of vinpocetine to achieve systemic absorption and a brain-targeting effect in rats. Carbopol acted as a gelling agent combined with hydroxypropyl methylcellulose (HPMC) as… read more here.
Keywords: vinpocetine; isg; ocular delivery; triggered situ ... See more keywords
Vinpocetine alleviates lung inflammation via macrophage inflammatory protein-1β inhibition in an ovalbumin-induced allergic asthma model
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DOI: 10.1371/journal.pone.0251012
Abstract: Asthma is a well-known bronchial disease that causes bronchial inflammation, narrowing of the bronchial tubes, and bronchial mucus secretion, leading to bronchial blockade. In this study, we investigated the association between phosphodiesterase (PDE), specifically PDE1,… read more here.
Keywords: vinpocetine; macrophage inflammatory; inflammatory protein; inflammation ... See more keywords
Vinpocetine is the forthcoming adjuvant agent in the management of COVID-19
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DOI: 10.2144/fsoa-2021-0099
Abstract: Vinpocetine (VPN) is an alkaloid derivative of vincamine inhibits phosphodiesterase type 1 that increase cyclic guanosine monophosphate and cyclic adenosine monophosphate. VPN have anti-inflammatory and antioxidant effects with suppression release of pro-inflammatory cytokines. Moreover, VPN… read more here.
Keywords: agent management; forthcoming adjuvant; vinpocetine; covid ... See more keywords
Vinpocetine’s immunomodulating, anti-oxidant, anti-inflammatory, ant-ifibrotic, and PDE inhibiting potencies ameliorate bleomycin-induced pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.64175.14130
Abstract: Objective(s): Pulmonary fibrosis (PF) is a global health problem with a high economic burden. Intratracheal administration of bleomycin is the best model that resembles the pathogenesis of PF in humans. Recently, vinpocetine proved to have… read more here.
Keywords: vinpocetine; immunomodulating anti; pulmonary fibrosis; bleomycin ... See more keywords
The protective effect of taurine, piracetam and vinpocetine on etoposide-induced inflammation and brain injury in the serum of female albino rats
Sign Up to like & getrecommendations! Published in 2023 at "ecancermedicalscience"
DOI: 10.3332/ecancer.2023.1499
Abstract: Etoposide (ETP) is one of the leading antitumour agents in cancer chemotherapy. Many studies have reported on ETP-induced peripheral neuropathy; however, few reports have focused on its brain toxicity. The current research investigates the protective… read more here.
Keywords: piracetam vinpocetine; vinpocetine; brain; taurine piracetam ... See more keywords