Palladium-Catalyzed 1,1-Alkynyloxygenation of 2-Vinylbenzoates with Alkynyl Bromides.
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DOI: 10.1021/acs.orglett.3c01008
Abstract: The palladium-catalyzed reaction of alkyl 2-vinylbenzoates with silyl-protected alkynyl bromides leads to the selective production of 3-alkynylated isochroman-1-ones. The use of an alkyl ester group as an effective oxygen nucleophile is crucial for the efficient… read more here.
Keywords: vinylbenzoates alkynyl; palladium catalyzed; alkynyloxygenation vinylbenzoates; alkynyl bromides ... See more keywords