The vinylogous aldol reaction of N-Sulfinyl metallodienamines
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DOI: 10.1016/j.tet.2019.130901
Abstract: Abstract The discovery and development of the vinylogous aldol reaction of N-sulfinyl metallodienamines with aldehydes and ketones is described. The diastereoselectivity of the reaction, first reported in 2017 as a key step in the total… read more here.
Keywords: reaction sulfinyl; aldol reaction; sulfinyl metallodienamines; vinylogous aldol ... See more keywords
Phosphine-Catalyzed Intramolecular Vinylogous Aldol Reaction of α-Substituted Enones.
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DOI: 10.1021/acs.orglett.1c03913
Abstract: We demonstrate the first phosphine-catalyzed intramolecular vinylogous aldol reaction (IVAR) of α-substituted enones. This strategy provides access to various pentannulated (hetero)arenes and dibenzocycloheptanones incorporated with two contiguous stereocenters, one of which is an all-carbon quaternary… read more here.
Keywords: phosphine catalyzed; intramolecular vinylogous; vinylogous aldol; aldol reaction ... See more keywords
Convergent Synthesis of Enantioenriched ortho-Fused Tricyclic Diketones via Catalytic Asymmetric Intramolecular Vinylogous Aldol Condensation.
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DOI: 10.1021/acs.orglett.2c03645
Abstract: Herein, we describe a catalytic asymmetric intramolecular vinylogous aldol reaction by taking advantage of dual organocatalysts, which enables convergent synthesis of ortho-fused tricyclic diketones in excellent enantioselectivities and diastereoselectivities. Noteworthy is that the reaction stereoselectively… read more here.
Keywords: asymmetric intramolecular; ortho fused; convergent synthesis; intramolecular vinylogous ... See more keywords