Desymmetrization Process by Mg(II)-Catalyzed Intramolecular Vinylogous Michael Reaction.
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DOI: 10.1021/acs.orglett.0c03417
Abstract: Chiral magnesium catalyzed intramolecular vinylogous Michael reaction of novel cyclohexadienones via a desymmetrization process is reported. (R)-BINOL derived ligand and an achiral amide were employed in the current in situ generated magnesium catalyst, giving the… read more here.
Keywords: vinylogous michael; michael reaction; intramolecular vinylogous; desymmetrization process ... See more keywords
Organocatalytic Enantioselective Vinylogous Michael-Aldol Cascade for the Synthesis of Spirocyclic Compounds.
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DOI: 10.1021/acs.orglett.7b02085
Abstract: Enantioselective synthesis of pyrazolone-fused spirocyclohexenols by the secondary amine-catalyzed cascade reaction of α,β-unsaturated aldehydes with α-arylidene pyrazolinones is reported. This formal [3 + 3] organocascade reaction proceeds through a vinylogous Michael-aldol sequence to furnish the… read more here.
Keywords: aldol cascade; michael aldol; organocatalytic enantioselective; vinylogous michael ... See more keywords