Chemically induced vinylphosphonothiolate electrophiles for thiol-thiol bioconjugations.
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DOI: 10.1021/jacs.0c03426
Abstract: Herein we introduce vinylphosphonothiolates as a new class of cysteine-selective electrophiles for protein labeling and the formation of stable protein-protein conjugates. We developed a straightforward synthetic route to convert nucleophilic thiols into electrophilic, thiol-selective vinylphosphonothiolates:… read more here.
Keywords: vinylphosphonothiolate electrophiles; electrophiles thiol; induced vinylphosphonothiolate; thiol thiol ... See more keywords