Unraveling the Reaction Mechanism of Russell's Viper Venom Factor X Activator: A Paradigm for the Reactivity of Zinc Metalloproteinases?
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DOI: 10.1021/acs.jcim.2c01156
Abstract: Snake venom metalloproteinases (SVMPs) are important drug targets against snakebite envenoming, the neglected tropical disease with the highest mortality worldwide. Here, we focus on Russell's viper (Daboia russelii), one of the "big four" snakes of… read more here.
Keywords: venom; russell viper; venom factor; viper venom ... See more keywords
Understanding Russell’s viper venom factor V activator’s substrate specificity by surface plasmon resonance and in-silico studies
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DOI: 10.1371/journal.pone.0181216
Abstract: Blood coagulation factor V (FV) is activated either by Factor X or thrombin, cleaving at three different sites viz., Site I (Arg709-Ser710), site II (Arg1018-Thr1019), and site III (Arg1545-Ser1546). Russell’s viper venom factor V activator… read more here.
Keywords: viper venom; factor activator; site; russell viper ... See more keywords
Viper Venom Phospholipase A2 Database: The Structural and Functional Anatomy of a Primary Toxin in Envenomation
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DOI: 10.3390/toxins16020071
Abstract: Viper venom phospholipase A2 enzymes (vvPLA2s) and phospholipase A2-like (PLA2-like) proteins are two of the principal toxins in viper venom that are responsible for the severe myotoxic and neurotoxic effects caused by snakebite envenoming, among… read more here.
Keywords: viper venom; database; anatomy; venom phospholipase ... See more keywords