Meiotic viral attenuation through an ancestral apoptotic pathway
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1900751116
Abstract: Significance A hypothesis for the paradoxical evolution of programmed cell death posits that suicide mechanisms were co-opted from processes that were originally pro-survival. Here we show that meiotically programmed mitochondrial release of the Endonuclease G… read more here.
Keywords: viral attenuation; mitochondrial release; pathway; endog ... See more keywords
A Molecular Determinant of West Nile Virus Secretion and Morphology as a Target for Viral Attenuation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.00086-20
Abstract: West Nile virus (WNV) is a worldwide (re)emerging mosquito-transmitted Flavivirus causing fatal neurological diseases in humans. However, no human vaccine has been yet approved. One of the most effective live-attenuated vaccines was empirically obtained by… read more here.
Keywords: wnv; attenuation; west nile; nile virus ... See more keywords
Viral attenuation by Endonuclease G during yeast gametogenesis: insights into ancestral roles of programmed cell death?
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Cell"
DOI: 10.15698/mic2020.02.705
Abstract: Viruses and other genetic parasites are present in virtually all forms of life. This chronic condition has led to diverse host cell adaptations such as CRISPR and RNAi, whose functions attenuate these parasites. It is… read more here.
Keywords: viral attenuation; programmed cell; cell; cell death ... See more keywords