Dynamics of salivary human herpesvirus‐6 and ‐7 shedding in pregnant women
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27692
Abstract: Reactivation of Betaherpesvirinae (Human herpesvirus 6A: HHV‐6A, ‐6B, HHV‐7) may be associated with mental illness and host fatigue. This study aimed to determine whether viral reactivation, measured by monitoring salivary viral DNA load, can be… read more here.
Keywords: dna load; dna; hhv; viral dna ... See more keywords
The cell-free DNA virome of 108,349 Dutch pregnant women.
Sign Up to like & getrecommendations! Published in 2022 at "Prenatal diagnosis"
DOI: 10.1002/pd.6143
Abstract: OBJECTIVE Viral infections during pregnancy are a major health concern to mother and fetus. By repurposing cell-free Non Invasive Prenatal Testing (NIPT) sequencing data, we investigated prevalence and abundance of viral DNA in a cohort… read more here.
Keywords: viral dna; dna; cell free; pregnant women ... See more keywords
Single-Molecule Measurements of Motor-Driven Viral DNA Packaging in Bacteriophages Phi29, Lambda, and T4 with Optical Tweezers.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8556-2_20
Abstract: Viral DNA packaging is a required step in the assembly of many dsDNA viruses. A molecular motor fueled by ATP hydrolysis packages the viral genome to near crystalline density inside a preformed prohead shell in… read more here.
Keywords: optical tweezers; dna; motor; dna packaging ... See more keywords
Profile of anti‐herpetic action of ASP2151 (amenamevir) as a helicase‐primase inhibitor
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2016.12.008
Abstract: &NA; The antiherpetic drugs acyclovir (ACV, valaciclovir) and penciclovir (famciclovir) are phosphorylated by viral thymidine kinase and terminate DNA synthesis. ASP2151 (amenamevir) and foscavir (PFA) directly inhibit viral helicase‐primase and DNA polymerase, respectively, and inhibit… read more here.
Keywords: dna synthesis; dna; asp2151; viral dna ... See more keywords
The inhibition process of HIV-1 integrase by diketoacids molecules: Understanding the factors governing the better efficiency of dolutegravir.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.001
Abstract: The Human Immunodeficiency Virus-1 integrase is responsible for the covalent insertion of a newly synthesized double-stranded viral DNA into the host cells, and is an emerging target for antivirus drug design. Raltegravir (RAL) and elvitegravir… read more here.
Keywords: integrase; process hiv; inhibition process; hiv integrase ... See more keywords
The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.09.016
Abstract: The retrovirus human T-cell leukemia virus type 1 (HTLV-1) integrates into the host DNA, achieves persistent infection, and induces human diseases. Here, we demonstrate that viral DNA-capture sequencing (DNA-capture-seq) is useful to characterize HTLV-1 proviruses… read more here.
Keywords: viral dna; htlv; capture seq; dna capture ... See more keywords
PddCas: A Polydisperse Droplet Digital CRISPR/Cas-Based Assay for the Rapid and Ultrasensitive Amplification-Free Detection of Viral DNA/RNA.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03590
Abstract: Clustered regularly interspaced short palindromic repeats (CRISPR)-based assays have been an emerging diagnostic technology for pathogen diagnosis. In this work, we developed a polydisperse droplet digital CRISPR-Cas-based assay (PddCas) for the rapid and ultrasensitive amplification-free… read more here.
Keywords: detection viral; crispr; viral dna; detection ... See more keywords
A shedding analysis after AAV8 CNS injection revealed fragmented viral DNA without evidence of functional AAV particles in mice
Sign Up to like & getrecommendations! Published in 2024 at "Gene Therapy"
DOI: 10.1038/s41434-024-00447-z
Abstract: Adeno-associated viruses (AAV) are commonly used in the scientific field due to their diverse application range. However, AAV shedding, the release of virions from the host organism, can impact the safety of AAV-based approaches. An… read more here.
Keywords: aav particles; aav; viral dna; particles mice ... See more keywords
N6-methyladenosine modification of a parvovirus-encoded small noncoding RNA facilitates viral DNA replication through recruiting Y-family DNA polymerases
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2320782121
Abstract: Significance Human bocavirus 1 (HBoV1), an autonomously replicating human parvovirus, is a human pathogen that causes lower respiratory tract infections in young children. HBoV1 expresses a small noncoding RNA (sncRNA), named bocavirus-encoded small RNA (BocaSR),… read more here.
Keywords: dna replication; viral dna; small noncoding; rna ... See more keywords
CRISPR/Cas9 Inhibits Multiple Steps of HIV-1 Infection.
Sign Up to like & getrecommendations! Published in 2018 at "Human gene therapy"
DOI: 10.1089/hum.2018.018
Abstract: CRISPR/Cas9 is an adaptive immune system where bacteria and archaea have evolved to resist the invading viruses and plasmid DNA by creating site-specific double-strand breaks in DNA. This study tested this gene editing system in… read more here.
Keywords: hiv infection; dna; crispr cas9; cas9 ... See more keywords
HIV serology false positivity among expatriates from Africa: a screening dilemma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.001186
Abstract: HIV prevalence in Oman is low (5 %). HIV screening is performed at regional public health laboratories as part of a medical fitness programme for residency applicants. We conducted a retrospective evaluation of indeterminate serology results… read more here.
Keywords: hiv serology; hiv; serology; prevalence ... See more keywords