Within-Host Viral Dynamics in a Multi-compartmental Environment
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-019-00658-1
Abstract: The discrepancy in the turnover of cells and virus in different organs or viral reservoirs necessitates the investigation of multiple compartments within a host. Establishing a multi-compartmental structure that describes the complexity of various organs,… read more here.
Keywords: host viral; viral dynamics; multi compartmental; within host ... See more keywords
Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06215-z
Abstract: Despite several clinical trials implemented, no antiviral drug could demonstrate efficacy against Ebola virus. In non-human primates, early initiation of polymerase inhibitors favipiravir and remdesivir improves survival, but whether they could be effective in patients… read more here.
Keywords: viral dynamics; dynamics nonhuman; ebola viral; immuno pathogenesis ... See more keywords
Environmental DNA monitoring of oncogenic viral shedding and genomic profiling of sea turtle fibropapillomatosis reveals unusual viral dynamics
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02085-2
Abstract: Pathogen-induced cancers account for 15% of human tumors and are a growing concern for endangered wildlife. Fibropapillomatosis is an expanding virally and environmentally co-induced sea turtle tumor epizootic. Chelonid herpesvirus 5 (ChHV5) is implicated as… read more here.
Keywords: viral dynamics; viral shedding; environmental dna; sea turtle ... See more keywords
A Deterministic Model for Understanding Nonlinear Viral Dynamics in Oysters
Sign Up to like & getrecommendations! Published in 2022 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.02360-21
Abstract: The fate of viruses in contaminated oysters has received a significant amount of attention in the fields of oyster aquaculture, food quality control, and public health. However, intensive studies through laboratory experiments and in situ… read more here.
Keywords: nonlinear viral; viral dynamics; oyster; model ... See more keywords
Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001333
Abstract: SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level persistent viral RNA shedding. The dynamics of viral RNA concentration, particularly in the early stages of infection, can inform… read more here.
Keywords: viral dynamics; acute sars; infection; dynamics acute ... See more keywords
Random time-shift approximation enables hierarchical Bayesian inference of mechanistic within-host viral dynamics models on large datasets.
Sign Up to like & getrecommendations! Published in 2025 at "PLoS computational biology"
DOI: 10.1371/journal.pcbi.1013775
Abstract: Mechanistic mathematical models of within-host viral dynamics are tools for understanding how a virus’ biology and its interaction with the immune system shape the infectivity of a host. The biology of the process is encoded… read more here.
Keywords: host viral; inference; biology; within host ... See more keywords
Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1328820
Abstract: Introduction Bluetongue virus (BTV) is an arthropod-borne Orbivirus that is almost solely transmitted by Culicoides biting midges and causes a globally important haemorrhagic disease, bluetongue (BT), in susceptible ruminants. Infection with BTV is characterised by… read more here.
Keywords: transmission; cell subsets; anti viral; specific cell ... See more keywords
Viral Dynamics in the Tropical Pacific Ocean: A Comparison between Within and Outside a Warm Eddy
Sign Up to like & getrecommendations! Published in 2024 at "Viruses"
DOI: 10.3390/v16060937
Abstract: In mesoscale eddies, the chemical properties and biological composition are different from those in the surrounding water due to their unique physical processes. The mechanism of physical–biological coupling in warm-core eddies is unclear, especially because… read more here.
Keywords: eddy; ocean; tropical pacific; warm eddy ... See more keywords
Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.48401
Abstract: Bats host virulent zoonotic viruses without experiencing disease. A mechanistic understanding of the impact of bats’ virus hosting capacities, including uniquely constitutive immune pathways, on cellular-scale viral dynamics is needed to elucidate zoonotic emergence. We… read more here.
Keywords: bat; emergence; viral dynamics; zoonotic emergence ... See more keywords