Viral entry mechanisms: the role of molecular simulation in unlocking a key step in viral infections
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13908
Abstract: Viral infections are a major global health concern, affecting millions of people each year. Viral entry is one of the crucial stages in the infection process, but its details remain elusive. Enveloped viruses are enclosed… read more here.
Keywords: fusion; viral infections; viral entry; simulation ... See more keywords
Enterovirus D68: A Novel Inhibitor Reveals Underlying Molecular Mechanisms of Viral Entry and Uncoating
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70677
Abstract: While enterovirus D68 (EV‐D68) has emerged as a significant pediatric pathogen causing severe respiratory illness and acute flaccid myelitis, no effective therapeutics exist. Through systematic screening of natural products, we identified geranyl‐p‐trans‐coumaric acid (GCA) as… read more here.
Keywords: viral entry; inhibitor; enterovirus d68; d68 ... See more keywords
iDVEIP: A computer‐aided approach for the prediction of viral entry inhibitory peptides
Sign Up to like & getrecommendations! Published in 2024 at "PROTEOMICS"
DOI: 10.1002/pmic.202300257
Abstract: With the notable surge in therapeutic peptide development, various peptides have emerged as potential agents against virus‐induced diseases. Viral entry inhibitory peptides (VEIPs), a subset of antiviral peptides (AVPs), offer a promising avenue as entry… read more here.
Keywords: viral entry; prediction; entry inhibitory; inhibitory peptides ... See more keywords
Systematic screening of viral entry inhibitors using surface plasmon resonance
Sign Up to like & getrecommendations! Published in 2017 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.1952
Abstract: Viral binding and entry into host cells for various viruses have been studied extensively, yielding a detailed understanding of the overall viral entry process. As cell entry is an essential and requisite process by which… read more here.
Keywords: screening viral; surface plasmon; entry; plasmon resonance ... See more keywords
Characterization of viral entry and infection of quantum dot-labeled grass carp reovirus
Sign Up to like & getrecommendations! Published in 2017 at "Virologica Sinica"
DOI: 10.1007/s12250-016-3903-5
Abstract: In this study, we characterized a QD-labeled nonenveloped aquareovirus. Our results showed that QDGCRVs maintained their native particle properties and showed excellent infectivity in host cells. To the best of our knowledge, this is the… read more here.
Keywords: characterization viral; infection; infection quantum; entry infection ... See more keywords
Antiviral lectins: Selective inhibitors of viral entry
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.03.007
Abstract: Abstract Many natural lectins have been reported to have antiviral activity. As some of these have been put forward as potential development candidates for preventing or treating viral infections, we have set out in this… read more here.
Keywords: reported antiviral; inhibitors viral; antiviral lectins; selective inhibitors ... See more keywords
Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry
Sign Up to like & getrecommendations! Published in 2022 at "Cell Metabolism"
DOI: 10.1016/j.cmet.2022.01.008
Abstract: Coronavirus disease 2019 (COVID-19) represents a systemic disease that may cause severe metabolic complications in multiple tissues including liver, kidney, and cardiovascular system. However, the underlying mechanisms and optimal treatment remain elusive. Our study shows… read more here.
Keywords: metabolic complications; covid; imatinib methazolamide; viral entry ... See more keywords
Organotypic human ex vivo models for coronavirus disease 2019 research and drug development
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2021.04.006
Abstract: Since the discovery of SARS-CoV-2 in late 2019, intense research efforts on an unprecedented scale have focused on the study of viral entry mechanisms and adaptive immunity. While the identification of ACE2 and other co-receptors… read more here.
Keywords: research; organotypic human; drug; human vivo ... See more keywords
Design of HIV Coreceptor Derived Peptides That Inhibit Viral Entry at Submicromolar Concentrations.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00155
Abstract: HIV/AIDS continues to pose an enormous burden on global health. Current HIV therapeutics include inhibitors that target the enzymes HIV protease, reverse transcriptase, and integrase, along with viral entry inhibitors that block the initial steps… read more here.
Keywords: hiv coreceptor; hiv; coreceptor; peptides inhibit ... See more keywords
Broad Tricyclic Ring Inhibitors Block SARS-CoV-2 Spike Function Required for Viral Entry
Sign Up to like & getrecommendations! Published in 2022 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.1c00658
Abstract: The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells requires binding of the viral spike glycoprotein to the angiotensin-converting enzyme 2 (ACE2) receptor, which triggers subsequent conformational changes to facilitate viral… read more here.
Keywords: cov spike; block sars; entry; tricyclic ring ... See more keywords
Direct inhibitory effect on viral entry of influenza A and SARS‐CoV‐2 viruses by azithromycin
Sign Up to like & getrecommendations! Published in 2020 at "Cell Proliferation"
DOI: 10.1111/cpr.12953
Abstract: Using strategy of drug repurposing, antiviral agents against influenza A virus (IAV) and newly emerging SARS‐coronavirus 2 (SARS‐CoV‐2, also as 2019‐nCoV) could be quickly screened out. read more here.
Keywords: entry influenza; effect viral; direct inhibitory; inhibitory effect ... See more keywords