Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes
Sign Up to like & getrecommendations! Published in 2018 at "Science Advances"
DOI: 10.1126/sciadv.aau8408
Abstract: Natural triterpenoids, as virus-host fusion inhibitors, exhibit potential in expanding the current repertoire of antiviral agents. A trimer-of-hairpins motif has been identified in triggering virus-cell fusion within a variety of viral envelopes. Chemically manipulating such… read more here.
Keywords: virus host; host fusion; viral envelopes; fusion ... See more keywords
Plantaricin NC8 αβ rapidly and efficiently inhibits flaviviruses and SARS-CoV-2 by disrupting their envelopes
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0278419
Abstract: Potent broad-spectrum antiviral agents are urgently needed to combat existing and emerging viral infections. This is particularly important considering that vaccine development is a costly and time consuming process and that viruses constantly mutate and… read more here.
Keywords: plantaricin nc8; antiviral agents; viral envelopes; virus ... See more keywords
Cholesterol in viral envelope determines infectivity of SARS-CoV-2 and other coronaviruses
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1670356
Abstract: The SARS-CoV-2 pandemic had unprecedented impacts on public health and the economy. Many studies have focused on the mechanisms of SARS-CoV-2 entry into host cells, particularly the spike (S) protein mediated receptor engagement and subsequent… read more here.
Keywords: sars cov; host; viral envelopes; infectivity sars ... See more keywords