Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26164-4
Abstract: Viral infection triggers activation of the integrated stress response (ISR). In response to viral double-stranded RNA (dsRNA), RNA-activated protein kinase (PKR) phosphorylates the translation initiation factor eIF2, converting it from a translation initiator into a… read more here.
Keywords: response; stress response; eif2 binding; viral evasion ... See more keywords
Viral evasion of PKR restriction by reprogramming cellular stress granules
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201169119
Abstract: Significance Evolutionarily conserved protein kinase R (PKR) is a powerful mediator of antiviral responses. Enigmatically, PKR activity is disabled by porcine reproductive and respiratory syndrome virus (PRRSV) during infection, while the virus still allows the… read more here.
Keywords: stress granules; pkr; evasion pkr; pkr restriction ... See more keywords