Advancements in the design and scalable production of viral gene transfer vectors
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26461
Abstract: The last 10 years have seen a rapid expansion in the use of viral gene transfer vectors, with approved therapies and late stage clinical trials underway for the treatment of genetic disorders, and multiple forms… read more here.
Keywords: gene transfer; transfer vectors; production; viral gene ... See more keywords
Oral Non-Viral Gene Delivery for Applications in DNA Vaccination and Gene Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in biomedical engineering"
DOI: 10.1016/j.cobme.2018.09.003
Abstract: Non-viral gene delivery via the oral route is a promising strategy for improving outcomes of DNA vaccination and gene therapy applications. Unlike traditional parenteral administration routes, the oral route is a non-invasive approach that lends… read more here.
Keywords: non viral; viral gene; gene delivery; gene ... See more keywords
Epstein-Barr virus: a master epigenetic manipulator.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2017.07.017
Abstract: Like all herpesviruses, the ability of Epstein-Barr virus (EBV) to establish life-long persistent infections is related to a biphasic viral lifecycle that involves latency and reactivation/lytic replication. Memory B cells serve as the EBV latency… read more here.
Keywords: barr virus; epstein barr; gene expression; viral gene ... See more keywords
Peptides mediating DNA transport on microtubules and their impact on non-viral gene transfer efficiency
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20170995
Abstract: Synthetic vectors such as cationic polymers and cationic lipids remain attractive tools for non-viral gene transfer which is a complex process whose effectiveness relies on the ability to deliver a plasmid DNA (pDNA) into the… read more here.
Keywords: non viral; viral gene; transport; gene transfer ... See more keywords
Update on Viral Gene Therapy Clinical Trials for Retinal Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Human Gene Therapy"
DOI: 10.1089/hum.2022.159
Abstract: In 2001, the first large animal was successfully treated with a gene therapy that restored its vision. Lancelot, the Briard dog that was treated, suffered from a human childhood blindness called Leber's congenital amaurosis type… read more here.
Keywords: update viral; viral gene; clinical trials; gene therapy ... See more keywords
Using Viral Gene Sequences to Compare and Explain the Heterogeneous Spatial Dynamics of Virus Epidemics
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msx176
Abstract: Rabies is an important zoonotic disease distributed worldwide. A key question in rabies epidemiology is the identification of factors that impact virus dispersion. Here we apply new analytical methods, based on phylogeographic reconstructions of viral… read more here.
Keywords: gene sequences; viral gene; using viral; factors impact ... See more keywords
The Viral Gene ORF79 Encodes a Repressor Regulating Induction of the Lytic Life Cycle in the Haloalkaliphilic Virus ϕCh1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00206-17
Abstract: ABSTRACT In this study, we describe the construction of the first genetically modified mutant of a halovirus infecting haloalkaliphilic Archaea. By random choice, we targeted ORF79, a currently uncharacterized viral gene of the haloalkaliphilic virus… read more here.
Keywords: repressor; viral gene; ch1; strain ... See more keywords
Deletion of Murine Gammaherpesvirus Gene M2 in Activation-Induced Cytidine Deaminase-Expressing B Cells Impairs Host Colonization and Viral Reactivation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.01933-20
Abstract: Gammaherpesviruses establish lifelong chronic infections in cells of the immune system that can lead to lymphomas and other diseases. To facilitate colonization of a host, gammaherpesviruses encode gene products that manipulate processes involved in cellular… read more here.
Keywords: system; viral gene; colonization; gene ... See more keywords
Non-viral gene delivery systems: hurdles for bench-to-bedside transformation.
Sign Up to like & getrecommendations! Published in 2017 at "Die Pharmazie"
DOI: 10.1691/ph.2017.7092
Abstract: Biologist and Nobel Prize winner James Watson's quote, "We used to think that our fate was in our stars, but now we know that, in large measure, our fate is in our genes", represents the… read more here.
Keywords: non viral; viral gene; delivery systems; gene delivery ... See more keywords
Endogenous viral gene ev21 is not responsible for the expression of late feathering in chickens
Sign Up to like & getrecommendations! Published in 2018 at "Poultry Science"
DOI: 10.3382/ps/pex345
Abstract: Abstract The late‐feathering (LF) gene K on the Z chromosome is an important gene in the chicken industry, which is frequently utilized for the feather sexing, a type of autosexing, of neonatal chicks. The K… read more here.
Keywords: viral gene; endogenous viral; ev21; expression ... See more keywords
Viral Gene Therapy for Glioblastoma Multiforme: A Promising Hope for the Current Dilemma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.678226
Abstract: Glioblastoma multiforme (GBM), as one of the most common malignant brain tumors, was limited in its treatment effectiveness with current options. Its invasive and infiltrative features led to tumor recurrence and poor prognosis. Effective treatment… read more here.
Keywords: gene; gene therapy; viral gene; glioblastoma multiforme ... See more keywords