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   Articles with "viral genes" as a keyword



CocoVax: a web server for codon-based deoptimization of viral genes in live attenuated vaccine design

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf358

Abstract: Abstract Viral infections pose major economic and public health challenges worldwide, with vaccines as a critical tool for prevention. Synonymous recoding of viral genes through codon and codon-pair deoptimization offers a promising approach to design… read more here.

Keywords: cocovax; deoptimization; viral genes; live attenuated ... See more keywords

Cell-Derived Viral Genes Evolve under Stronger Purifying Selection in Rhadinoviruses

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recommendations! Published in 2018 at "Journal of Virology"

DOI: 10.1128/jvi.00359-18

Abstract: Viruses and hosts have been shown to capture genes from one another as part of the evolutionary arms race. Such genes offer a natural experiment on the effects of evolutionary pressure, since the same gene… read more here.

Keywords: derived viral; genes evolve; host; viral genes ... See more keywords
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Longitudinal transcriptomic characterization of viral genes in HSV-1 infected tree shrew trigeminal ganglia

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recommendations! Published in 2020 at "Virology Journal"

DOI: 10.1186/s12985-020-01344-8

Abstract: Background Following acute infection, Herpes Simplex virus-1 (HSV-1) establishes lifelong latency and recurrent reactivation in the sensory neurons of trigeminal ganglia (TG). Infected tree shrew differs from mouse and show characteristics similar to human infection.… read more here.

Keywords: trigeminal ganglia; tree shrew; infection; infected tree ... See more keywords

MAP3K15 facilitates multiple viral genes expression in crustaceans via Dorsal-CC-CL-STAT axis besides the JNK/P38 pathway

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recommendations! Published in 2025 at "PLOS Pathogens"

DOI: 10.1371/journal.ppat.1013349

Abstract: The mitogen-activated protein kinase (MAPK) pathway is a conserved signaling system that responds to extracellular signals and translates them into appropriate cellular responses. While multiple MAPK kinase kinases (MAP3Ks) play a crucial role in the… read more here.

Keywords: viral genes; jnk p38; infection; expression ... See more keywords

CRISPR Interference Efficiently Silences Latent and Lytic Viral Genes in Kaposi’s Sarcoma-Associated Herpesvirus-Infected Cells

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recommendations! Published in 2021 at "Viruses"

DOI: 10.3390/v13050783

Abstract: Uncovering viral gene functions requires the modulation of gene expression through overexpression or loss-of-function. CRISPR interference (CRISPRi), a modification of the CRISPR-Cas9 gene editing technology, allows specific and efficient transcriptional silencing without genetic ablation. CRISPRi… read more here.

Keywords: crispr interference; kaposi sarcoma; sarcoma associated; lytic viral ... See more keywords