Viral genome search in myocardium of patients with fulminant myocarditis
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1738
Abstract: 1BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK; 2Department of Radiology, Glasgow Royal Infirmary, Glasgow, UK; 3Division of Medical Physics, University of Leeds, Leeds, UK; 4Department of… read more here.
Keywords: myocardium patients; genome search; university; search myocardium ... See more keywords
Viral Genome Isolation from Human Faeces for Succession Assessment of the Human Gut Virome.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8682-8_8
Abstract: Despite the important role of the microbiota in the human gastrointestinal tract (GIT) and its impact on life-long health, the successional process through which this microbial community develops during infancy is still poorly understood. Specially,… read more here.
Keywords: faeces succession; isolation human; human faeces; genome isolation ... See more keywords
A defective viral genome strategy elicits broad protective immunity against respiratory viruses
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.11.023
Abstract: RNA viruses generate defective viral genomes (DVG) that can interfere with replication of the parental wild-type virus. To examine their therapeutic potential, we created a DVG by deleting the capsid-coding region of poliovirus. Strikingly, intraperitoneal… read more here.
Keywords: genome strategy; defective viral; strategy elicits; sars cov ... See more keywords
Analysis of IAV Replication and Co-infection Dynamics by a Versatile RNA Viral Genome Labeling Method.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.021
Abstract: Genome delivery to the proper cellular compartment for transcription and replication is a primary goal of viruses. However, methods for analyzing viral genome localization and differentiating genomes with high identity are lacking, making it difficult… read more here.
Keywords: replication infection; infection dynamics; genome labeling; rna viral ... See more keywords
Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46609-7
Abstract: Despite the high global prevalence of chronic hepatitis B (CHB) infection, datasets covering the whole hepatitis B viral genome from large patient cohorts are lacking, greatly limiting our understanding of the viral genetic factors involved… read more here.
Keywords: large scale; genome analysis; chronically infected; viral genome ... See more keywords
AccuVIR: an ACCUrate VIRal genome assembly tool for third-generation sequencing data.
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac827
Abstract: MOTIVATION RNA viruses tend to mutate constantly. While many of the variants are neutral, some can lead to higher transmissibility or virulence. Accurate assembly of complete viral genomes enables identification of underlying variants, which are… read more here.
Keywords: third generation; viral genome; genome assembly; generation sequencing ... See more keywords
The complexity landscape of viral genomes
Sign Up to like & getrecommendations! Published in 2022 at "GigaScience"
DOI: 10.1093/gigascience/giac079
Abstract: Abstract Background Viruses are among the shortest yet highly abundant species that harbor minimal instructions to infect cells, adapt, multiply, and exist. However, with the current substantial availability of viral genome sequences, the scientific repertory… read more here.
Keywords: methodology; viral genome; complexity landscape; viral genomes ... See more keywords
Function of a viral genome packaging motor from bacteriophage T4 is insensitive to DNA sequence
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa875
Abstract: Abstract Many viruses employ ATP-powered motors during assembly to translocate DNA into procapsid shells. Previous reports raise the question if motor function is modulated by substrate DNA sequence: (i) the phage T4 motor exhibits large… read more here.
Keywords: motor; function; dna sequence; sequence ... See more keywords
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1303
Abstract: Abstract The SARS-CoV-2 coronavirus is the causal agent of the current global pandemic. SARS-CoV-2 belongs to an order, Nidovirales, with very large RNA genomes. It is proposed that the fidelity of coronavirus (CoV) genome replication… read more here.
Keywords: nsp10 complex; sars cov; viral genome; inhibitor ... See more keywords
Human Papillomavirus 16 E2 Interaction with TopBP1 Is Required for E2 and Viral Genome Stability during the Viral Life Cycle
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00063-23
Abstract: ABSTRACT CK2 phosphorylation of HPV16 E2 at serine 23 promotes interaction with TopBP1, and this interaction is important for E2 plasmid segregation function. Here, we demonstrate that the E2-TopBP1 interaction is critical for E2 and… read more here.
Keywords: interaction; viral genome; topbp1 interaction; life ... See more keywords
Experimental Support for Human Papillomavirus Genome Amplification Early after Infectious Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00214-23
Abstract: It is being assumed that human papillomavirus (HPV) utilizes three different modes of replication during its life cycle: initial amplification during the establishment phase, genome maintenance, and differentiation-induced amplification. However, HPV16 initial amplification was never… read more here.
Keywords: infection model; viral genome; amplification; genome ... See more keywords