Activation of TLR4 by viral glycoproteins: A double-edged sword?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1007081
Abstract: Recognition of viral infection by pattern recognition receptors is paramount for a successful immune response to viral infection. However, an unbalanced proinflammatory response can be detrimental to the host. Recently, multiple studies have identified that… read more here.
Keywords: activation tlr4; tlr4 viral; viral glycoproteins; virus ... See more keywords
Two Sides to Every Story: Herpes Simplex Type-1 Viral Glycoproteins gB, gD, gH/gL, gK, and Cellular Receptors Function as Key Players in Membrane Fusion
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13091849
Abstract: Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) are prototypical alphaherpesviruses that are characterized by their unique properties to infect trigeminal and dorsal root ganglionic neurons, respectively, and establish life-long latent infections. These viruses initially… read more here.
Keywords: cellular receptors; membrane fusion; viral glycoproteins; herpes simplex ... See more keywords
Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13102076
Abstract: Infections with viral pathogens are widespread and can cause a variety of different diseases. In-depth knowledge about viral triggers initiating an immune response is necessary to decipher viral pathogenesis. Inflammasomes, as part of the innate… read more here.
Keywords: inflammasome activation; activation pyroptosis; activation; nlrp3 inflammasome ... See more keywords