Continuous low pH viral inactivation: Operation and scaling strategy informs viral clearance study
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28117
Abstract: A continuous viral inactivation (CVI) tubular reactor was designed for low pH viral inactivation within a continuous downstream system across multiple scales of operation. The reactors were designed to provide a minimum residence time of… read more here.
Keywords: operation; inactivation operation; low viral; viral inactivation ... See more keywords
Arginine‐enveloped virus inactivation and potential mechanisms
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DOI: 10.1002/btpr.2931
Abstract: Arginine synergistically inactivates enveloped viruses at a pH or temperature that does little harm to proteins, making it a desired process for therapeutic protein manufacturing. However, the mechanisms and optimal conditions for inactivation are not… read more here.
Keywords: enveloped viruses; viral inactivation; arginine; inactivation ... See more keywords
Comparison of viral inactivation methods on the characteristics of extracellular vesicles from SARS‐CoV‐2 infected human lung epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12291
Abstract: Abstract The interaction of SARS‐CoV‐2 infection with extracellular vesicles (EVs) is of particular interest at the moment. Studying SARS‐CoV‐2 contaminated‐EV isolates in instruments located outside of the biosafety level‐3 (BSL‐3) environment requires knowing how viral… read more here.
Keywords: extracellular vesicles; inactivation methods; cov infected; viral inactivation ... See more keywords
Validation of Viral Inactivation Protocols for Therapeutic Blood Products against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
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DOI: 10.3390/v14112419
Abstract: Therapeutic blood products including convalescent plasma/serum and immunoglobulins concentrated from convalescent plasma, such as intravenous immunoglobulins or hyperimmune globulins, and monoclonal antibodies are passive immunotherapy options for novel coronavirus disease 2019 (COVID-19). They have been… read more here.
Keywords: therapeutic blood; blood products; viral inactivation; sars cov ... See more keywords