Broad‐Spectrum Antiviral Agents Based on Multivalent Inhibitors of Viral Infectivity
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202001433
Abstract: Abstract The ongoing pandemic of the coronavirus disease (Covid‐19), caused by the spread of the severe acute respiratory syndrome coronavirus 2 (SARS CoV‐2), highlights the need for broad‐spectrum antiviral drugs. In this Essay, it is… read more here.
Keywords: multivalent inhibitors; spectrum antiviral; inhibitors viral; broad spectrum ... See more keywords
Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104649
Abstract: Herpesviral deubiquitinating enzymes (DUBs) were discovered in 2005, are highly conserved across the family, and are proving to be increasingly important players in herpesviral infection. EBV's DUB, BPLF1, is known to regulate both cellular and… read more here.
Keywords: bplf1; molecule screening; small molecule; screening identifies ... See more keywords
Collective properties of viral infectivity.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2018.06.001
Abstract: Individual virions typically fail to infect cells. Such decoupling between virions and infectious units is most evident in multicomponent and other segmented viruses, but is also frequent in non-segmented viruses. Despite being a well-known observation,… read more here.
Keywords: virion; properties viral; virology; collective properties ... See more keywords
Probability of Immobilization on Host Cell Surface Regulates Viral Infectivity.
Sign Up to like & getrecommendations! Published in 2020 at "Physical review letters"
DOI: 10.1103/physrevlett.125.128101
Abstract: The efficiency of a virus to establish its infection in host cells varies broadly among viruses. It remains unclear if there is a key step in this process that controls viral infectivity. To address this… read more here.
Keywords: cell surface; viral infectivity; cell; host ... See more keywords
Role for N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq8678
Abstract: Functional and epidemiological data suggest that N-linked glycans on the SARS-CoV-2 Spike protein may contribute to viral infectivity. To investigate this, we created a panel of N-to-Q mutations at N-glycosylation sites proximal to the Spike… read more here.
Keywords: calnexin calreticulin; cov spike; viral infectivity; calreticulin chaperones ... See more keywords