Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
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DOI: 10.1038/s41467-019-08810-0
Abstract: Productive HIV-1 replication requires viral integrase (IN), which catalyzes integration of the viral genome into the host cell DNA. IN, however, is short lived and is rapidly degraded by the host ubiquitin-proteasome system. To identify… read more here.
Keywords: hiv infection; degradation; microscopy; viral integrase ... See more keywords