Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
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DOI: 10.1038/s41586-020-2844-1
Abstract: Cancer therapies that target epigenetic repressors can mediate their effects by activating retroelements within the human genome. Retroelement transcripts can form double-stranded RNA (dsRNA) that activates the MDA5 pattern recognition receptor 1 – 6 .… read more here.
Keywords: epigenetic therapy; viral mimicry; inverted repeat; epigenetic therapies ... See more keywords
Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8
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DOI: 10.1128/mbio.00402-22
Abstract: Patients infected with SARS-CoV-2 variants lacking open reading frame 8 (ORF8) have been associated with milder infection and disease outcome, but the molecular mechanism behind how this viral accessory protein mediates disease pathogenesis is not… read more here.
Keywords: cov orf8; viral mimicry; orf8 viral; interleukin 17a ... See more keywords
Abstract IA05: Viral Mimicry in Pancreatic Cancer
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DOI: 10.1158/1538-7445.epimetab20-ia05
Abstract: With an overall survival rate of about 8% after five years, ductal adenocarcinoma of the pancreas (PDAC) is one of the cancers with the worst prognosis (Cancer Research UK and American Cancer Society). A hallmark… read more here.
Keywords: abstract ia05; pancreatic cancer; viral mimicry; mimicry pancreatic ... See more keywords
Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity.
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DOI: 10.1158/2159-8290.cd-20-1741
Abstract: The repression of repetitive elements is an important facet of p53's function as a guardian of the genome. Paradoxically, we found that p53 activated by MDM2 inhibitors induced the expression of endogenous retroviruses (ERVs) via… read more here.
Keywords: viral mimicry; tumor immune; tumor; p53 ... See more keywords
Inhibiting the Mitochondrial RNA Degradosome Complex SUV3 and Pnpase Increases dsRNA in the Cytoplasm, Triggers a Viral Mimicry Response and Kills AML Cells and Progenitors
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DOI: 10.1182/blood-2022-158326
Abstract: Eukaryotic cells have two separate genomes; nuclear chromosomal DNA and circular mitochondrial DNA. Mitochondrial DNA lacks introns, and encodes 2 rRNAs, 22 t-RNAs and 13 of the 90 proteins that constitute the mitochondrial respiratory chain.… read more here.
Keywords: response; pnpt1 supv3l1; aml cells; viral mimicry ... See more keywords