The impact of cerebrospinal fluid viral polymerase chain reaction testing on the management of adults with viral meningitis: A multi‐center retrospective study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28198
Abstract: The aim of this study was to evaluate the role of viral polymerase chain reaction (PCR) testing in patients with aseptic meningitis and identify opportunities for improvement in clinical management. All cerebrospinal fluid samples collected… read more here.
Keywords: chain reaction; polymerase chain; meningitis; cerebrospinal fluid ... See more keywords
Biochemical characterization of avian influenza viral polymerase containing PA or PB2 subunit from human influenza A virus.
Sign Up to like & getrecommendations! Published in 2018 at "Microbes and infection"
DOI: 10.1016/j.micinf.2018.04.003
Abstract: Adaptive mutations in viral polymerase, which is composed of PB1, PB2, and PA, of avian influenza viruses are major genetic determinants of the host range. In this study, to elucidate the molecular mechanism of mammalian… read more here.
Keywords: human influenza; avian influenza; wsn; polymerase ... See more keywords
Orally Efficacious Broad-Spectrum Allosteric Inhibitor of Paramyxovirus Polymerase
Sign Up to like & getrecommendations! Published in 2020 at "Nature microbiology"
DOI: 10.1038/s41564-020-0752-7
Abstract: Paramyxoviruses such as human parainfluenza virus type-3 (HPIV3) and measles virus (MeV) are a substantial health threat. In a high-throughput screen for inhibitors of HPIV3 (a major cause of acute respiratory infection), we identified GHP-88309—a… read more here.
Keywords: spectrum allosteric; hpiv3; polymerase; viral polymerase ... See more keywords
A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-54903-7
Abstract: Human norovirus is the leading cause of acute gastroenteritis worldwide, affecting every year 685 million people. In about one third of cases, this virus affects children under five years of age, causing each year up… read more here.
Keywords: norovirus; human norovirus; new antiviral; viral polymerase ... See more keywords
Determinants of Antibiotic Tailoring in Pediatric Intensive Care: A National Survey*
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Critical Care Medicine"
DOI: 10.1097/pcc.0000000000001238
Abstract: Objectives: To describe the criteria that currently guide empiric antibiotic treatment in children admitted to Canadian PICUs. Design: Cross-sectional survey. Setting: Canadian PICUs. Subjects: Pediatric intensivists and pediatric infectious diseases specialists. Interventions: None. Measurements and… read more here.
Keywords: positive viral; survey; chain reaction; polymerase chain ... See more keywords
Development of a Genetically Stable Live Attenuated Influenza Vaccine Strain Using an Engineered High-Fidelity Viral Polymerase
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.00493-21
Abstract: The LAIV currently in use is prescribed for actively immunizing individuals aged 2 to 49 years. However, it is not approved for infants and elderly individuals, who actually need it the most, because it might prolong… read more here.
Keywords: high fidelity; virus; strain; polymerase ... See more keywords
p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010295
Abstract: Many cellular genes and networks induced in human lung epithelial cells infected with the influenza virus remain uncharacterized. Here, we find that p21 levels are elevated in response to influenza A virus (IAV) infection, which… read more here.
Keywords: polymerase; p21 restricts; perturbing viral; polymerase complex ... See more keywords
Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Viruses"
DOI: 10.3390/v11020173
Abstract: Viral gastroenteritis is an important cause of morbidity and mortality worldwide, being particularly severe for children under the age of five. The most common viral agents of gastroenteritis are noroviruses, rotaviruses, sapoviruses, astroviruses and adenoviruses,… read more here.
Keywords: spectrum antiviral; diarrhea causing; polymerase; viral polymerase ... See more keywords