Transcriptomic features reveal molecular signatures associated with recombinant adeno-associated virus production in HEK293 cells.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology progress"
DOI: 10.1002/btpr.3346
Abstract: The development of gene therapies based on recombinant adeno-associated viruses (rAAVs) has grown exponentially, so the current rAAV manufacturing platform needs to be more efficient to satisfy rising demands. Viral production exerts great demand on… read more here.
Keywords: transcriptomic features; recombinant adeno; adeno associated; viral production ... See more keywords
SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production
Sign Up to like & getrecommendations! Published in 2021 at "Science Bulletin"
DOI: 10.1016/j.scib.2021.01.013
Abstract: A key to tackling the coronavirus disease 2019 (COVID-19) pandemic is to understand how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manages to outsmart host antiviral defense mechanisms. Stress granules (SGs), which are assembled during… read more here.
Keywords: protein; phase; stress granules; viral production ... See more keywords
A thermal trade-off between viral production and degradation drives virus-phytoplankton population dynamics.
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DOI: 10.1111/ele.13722
Abstract: Marine viruses interact with microbial hosts in dynamic environments shaped by variation in abiotic factors, including temperature. However, the impacts of temperature on viral infection of phytoplankton are not well understood. Here we coupled mathematical… read more here.
Keywords: viral production; temperature; virus phytoplankton; production degradation ... See more keywords
TDP-43 Controls HIV-1 Viral Production and Virus Infectiveness
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DOI: 10.3390/ijms24087658
Abstract: The transactive response DNA-binding protein (TARDBP/TDP-43) is known to stabilize the anti-HIV-1 factor, histone deacetylase 6 (HDAC6). TDP-43 has been reported to determine cell permissivity to HIV-1 fusion and infection acting on tubulin-deacetylase HDAC6. Here,… read more here.
Keywords: viral production; pr55gag; production; hiv viral ... See more keywords