Prenylation of viral proteins by enzymes of the host: Virus‐driven rationale for therapy with statins and FT/GGT1 inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700014
Abstract: Intracellular bacteria were recently shown to employ eukaryotic prenylation system for modifying activity and ensuring proper intracellular localization of their own proteins. Following the same logic, the proteins of viruses may also serve as prenylation… read more here.
Keywords: proteins enzymes; virus; prenylation viral; enzymes host ... See more keywords
Viral internal ribosomal entry sites: four classes for one goal
Sign Up to like & getrecommendations! Published in 2018 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1458
Abstract: To ensure efficient propagation, viruses need to rapidly produce viral proteins after cell entrance. Since viral genomes do not encode any components of the protein biosynthesis machinery, viral proteins must be produced by the host… read more here.
Keywords: viral internal; four classes; translation; viral proteins ... See more keywords
Cap-Snatching Leads to Novel Viral Proteins
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DOI: 10.1016/j.cell.2020.05.044
Abstract: Some negative-sense RNA viruses prime mRNA transcription using host 5' cap sequences, usurping host translational machinery and evading antiviral surveillance. In this issue of Cell, Ho et al. identify an additional consequence of this viral strategy:… read more here.
Keywords: leads novel; novel viral; snatching leads; cap snatching ... See more keywords
The dual role of phytochemicals on SARS-CoV-2 inhibition by targeting host and viral proteins
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2021.09.001
Abstract: Background The severe acute respiratory syndrome-2019 has affected more than 190 million people around the world and caused severe crises throughout the globe. Due to rapid mutation in the viral genome, it became important to… read more here.
Keywords: role phytochemicals; phytochemicals sars; host viral; dual role ... See more keywords
The protein-protein interactions between Amsacta moorei entomopoxvirus (AMEV) protein kinases (PKs) and all viral proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Virus research"
DOI: 10.1016/j.virusres.2018.02.007
Abstract: Entomopoxviruses are an important group of viruses infecting only insects. They belong to Poxviridae which infect both invertebrates and vertebrates, including humans. Protein kinases are known to have roles at virus morphogenesis, host selectivity, the… read more here.
Keywords: protein; moorei entomopoxvirus; amsacta moorei; kinases pks ... See more keywords
Ubiquitination of Zika Virus Precursor Membrane Protein Promotes the Release of Viral Proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Virus research"
DOI: 10.1016/j.virusres.2020.198065
Abstract: Zika virus (ZIKV) is an important human pathogen associated with severe neurological disorders. Ubiquitination of viral proteins has diverse roles in viral life cycle and pathogenesis. Here, we found that perturbation of ubiquitin-proteasome system significantly… read more here.
Keywords: protein; prm; precursor membrane; viral proteins ... See more keywords
Isarubrolone C Promotes Autophagic Degradation of Virus Proteins via Activating ATG10S in HepG2 Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c01161
Abstract: Isarubrolone C is a bioactive polycyclic tropoloalkaloid from Streptomyces. Our previous study showed that isarubrolone C could trigger autophagy. Here, we report isarubrolone C potential in broad-spectrum antiviral effect and its antiviral mechanism in vitro.… read more here.
Keywords: autophagic degradation; viral proteins; proteins via; isarubrolone promotes ... See more keywords
Targeting viral proteins for restraining SARS-CoV-2: focusing lens on viral proteins beyond spike for discovering new drug targets
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2175812
Abstract: ABSTRACT Introduction Emergence of highly infectious SARS-CoV-2 variants are reducing protection provided by current vaccines, requiring constant updates in antiviral approaches. The virus encodes four structural and sixteen nonstructural proteins which play important roles in… read more here.
Keywords: viral proteins; targeting viral; proteins restraining; restraining sars ... See more keywords
Glycosylation of viral proteins: Implication in virus–host interaction and virulence
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DOI: 10.1080/21505594.2022.2060464
Abstract: ABSTRACT Glycans are among the most important cell molecular components. However, given their structural diversity, their functions have not been fully explored. Glycosylation is a vital post-translational modification for various proteins. Many bacteria and viruses… read more here.
Keywords: viral proteins; glycosylation viral; linked glycosylation; glycosylation ... See more keywords
virusMED: an atlas of hotspots of viral proteins.
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DOI: 10.1107/s2052252521009076
Abstract: Metal binding sites, antigen epitopes and drug binding sites are the hotspots in viral proteins that control how viruses interact with their hosts. virusMED (virus Metal binding sites, Epitopes and Drug binding sites) is a… read more here.
Keywords: hotspots viral; binding sites; virusmed atlas; atlas hotspots ... See more keywords
Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01336-22
Abstract: We have found that human cytomegalovirus (HCMV) utilizes multiple viral proteins in multiple pathways to regulate a ubiquitous cellular basement membrane protein, nidogen-1 (NID1). The extent of the resources and the redundant methods that the… read more here.
Keywords: basement membrane; viral proteins; hcmv; membrane protein ... See more keywords