Incidence of Viral Rebound After Treatment With Nirmatrelvir-Ritonavir and Molnupiravir
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.45086
Abstract: Key Points Question What is the incidence of viral rebound after treatment with nirmatrelvir-ritonavir and molnupiravir? Findings In this cohort study of 12 629 adults in Hong Kong with COVID-19 who were hospitalized and had serial… read more here.
Keywords: nirmatrelvir ritonavir; ritonavir molnupiravir; viral rebound; treatment nirmatrelvir ... See more keywords
Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on‐going viral transcription
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25453
Abstract: Viral remission after analytical treatment interruption (ATI), termed post‐treatment control, has been described in a small proportion of HIV‐positive patients. This phenomenon has been separately associated to both low levels of HIV‐1 proviral DNA as… read more here.
Keywords: viral rebound; treatment; treatment interruption; analytical treatment ... See more keywords
A flexible nonlinear mixed effects model for HIV viral load rebound after treatment interruption.
Sign Up to like & getrecommendations! Published in 2020 at "Statistics in medicine"
DOI: 10.1002/sim.8529
Abstract: Characterization of HIV viral rebound after the discontinuation of antiretroviral therapy is central to HIV cure research. We propose a parametric nonlinear mixed effects model for the viral rebound trajectory, which often has a rapid… read more here.
Keywords: rebound; hiv viral; viral rebound; viral load ... See more keywords
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
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DOI: 10.1038/s41467-019-09725-6
Abstract: A major barrier to human immunodeficiency virus (HIV) cure is the existence of viral reservoirs that lead to viral rebound following discontinuation of antiretroviral therapy (ART). We postulate that enhancing cytotoxic T lymphocytes (CTL) targeting… read more here.
Keywords: viral rebound; rebound art; art free; shiv ... See more keywords
Antibody and TLR7 Agonist Delay Viral Rebound in SHIV-Infected Monkeys
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0600-6
Abstract: The latent viral reservoir is the critical barrier for the development of a cure for HIV-1 infection. Previous studies have shown direct antiviral activity of potent HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) administered when antiretroviral therapy… read more here.
Keywords: viral reservoir; rebound; antibody; viral rebound ... See more keywords
Transient viral rebound in children with perinatally acquired HIV-1 induces a unique soluble immunometabolic signature associated with decreased CD4/CD8 ratio.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/piad008
Abstract: BACKGROUND To determine by multi-omic analysis changes in metabolites, lipids and proteins as consequence of transient viral rebound (tVR) in children with perinatally acquired HIV-1 (PHIV). METHODS Plasma samples from children with PHIV and with… read more here.
Keywords: cd4 cd8; transient viral; viral rebound; tvr ... See more keywords
Evaluating HIV Viral Rebound Among Persons on Suppressive Antiretroviral Treatment in the Era of “Undetectable Equals Untransmittable (U = U)”
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DOI: 10.1093/ofid/ofaa529
Abstract: Abstract Background Studies have demonstrated that persons with HIV (PWH) maintaining viral suppression do not transmit HIV to HIV-negative partners through condomless sex, leading to the “Undetectable = Untransmittable (U = U)” prevention campaign. However, few studies have examined… read more here.
Keywords: suppression; era; viral rebound; 200 copies ... See more keywords
Risk of HIV Viral Rebound in the Era of Universal Treatment in a Multi-Center Sample of Persons with HIV in Primary Care
Sign Up to like & getrecommendations! Published in 2023 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofad257
Abstract: Antiretroviral therapy (ART) is recommended for people with HIV (PWH), irrespective of CD4 cell count, to improve their health and reduce the risk of transmission to sexual partners through long-term viral suppression. We identified risk… read more here.
Keywords: year; sustained viral; rebound; viral suppression ... See more keywords
Time to viral rebound and safety after antiretroviral treatment interruption in postpartum women compared to men.
Sign Up to like & getrecommendations! Published in 2019 at "AIDS"
DOI: 10.1097/qad.0000000000002334
Abstract: OBJECTIVE(S) The short-term safety of treatment interruptions, a necessary part of cure studies, is not well-established, particularly in women. We explored viral rebound kinetics and safety in a group of postpartum women discontinuing ART and… read more here.
Keywords: time; treatment; postpartum women; viral rebound ... See more keywords
Plasma and antibody glycomic biomarkers of time to HIV rebound and viral setpoint.
Sign Up to like & getrecommendations! Published in 2020 at "AIDS"
DOI: 10.1097/qad.0000000000002476
Abstract: OBJECTIVE HIV cure research urgently needs to identify pre-Analytic Treatment Interruption (ATI) biomarkers of time-to-viral-rebound and viral setpoint to mitigate the risk of ATI and accelerate development of a cure. We previously reported that galactosylated… read more here.
Keywords: viral setpoint; time; viral rebound; rebound viral ... See more keywords
Impact of antiretroviral therapy in primary HIV infection on natural killer cell function and the association with viral rebound and HIV DNA following treatment interruption
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.878743
Abstract: Natural Killer (NK) cells play a key role in controlling HIV replication, with potential downstream impact on the size of the HIV reservoir and likelihood of viral rebound after antiretroviral therapy (ART) cessation. It is… read more here.
Keywords: cell; hiv dna; hiv; viral rebound ... See more keywords