The Alphabet Soup of HIV Reservoir Markers
Sign Up to like & getrecommendations! Published in 2017 at "Current HIV/AIDS Reports"
DOI: 10.1007/s11904-017-0355-y
Abstract: Purpose of ReviewDespite the success of antiretroviral therapy in suppressing HIV, life-long therapy is required to avoid HIV reactivation from long-lived viral reservoirs. Currently, there is intense interest in searching for therapeutic interventions that can… read more here.
Keywords: reservoir; viral reservoir; hiv; replication competent ... See more keywords
Extremely low viral reservoir in treated chronically HIV-1-infected individuals
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102830
Abstract: Background Small viral reservoirs are found predominantly in HIV-1 controllers and individuals treated during acute/early HIV-1 infection. However, other HIV+ individuals could naturally also harbour low viral reservoirs. Methods We screened 451 HIV-1-infected treated-individuals with… read more here.
Keywords: hiv dna; viral reservoir; hiv; low viral ... See more keywords
For Viral Reservoir Studies, Timing Matters.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in microbiology"
DOI: 10.1016/j.tim.2019.08.003
Abstract: New strategies to eliminate persistent HIV-1 during therapy will benefit from animal models, such as non-human primates infected with simian immunodeficiency viruses (SIV) or chimeras (SHIV). Understanding the genetic composition of SIV and SHIV reservoirs… read more here.
Keywords: timing matters; studies timing; reservoir studies; viral reservoir ... See more keywords
Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21724-0
Abstract: The establishment of a long-lived viral reservoir is the key obstacle for achieving an HIV-1 cure. However, the anatomic, virologic, and immunologic features of the viral reservoir in tissues during antiretroviral therapy (ART) remain poorly… read more here.
Keywords: viral reservoir; rna; rhesus macaques; viral rna ... See more keywords
Antibody and TLR7 Agonist Delay Viral Rebound in SHIV-Infected Monkeys
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0600-6
Abstract: The latent viral reservoir is the critical barrier for the development of a cure for HIV-1 infection. Previous studies have shown direct antiviral activity of potent HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) administered when antiretroviral therapy… read more here.
Keywords: viral reservoir; rebound; antibody; viral rebound ... See more keywords
Qualitative plasma viral load determination as a tool for screening of viral reservoir size in PWH
Sign Up to like & getrecommendations! Published in 2022 at "AIDS"
DOI: 10.1097/qad.0000000000003352
Abstract: Objective(s): Suppression of viral replication in patients on antiretroviral therapy (ART) is determined by plasma viral load (pVL) measurement. Whenever pVL reaches values below the limit of quantification, the qualitative parameter ’target detected’ or ’target… read more here.
Keywords: reservoir; ptd; viral reservoir; pvl ... See more keywords
HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02)
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00823
Abstract: Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic vaccines to induce effective cytotoxic immune responses hold potential to achieve a functional cure for HIV-1 infection. Here, we report on an open-label,… read more here.
Keywords: infected individuals; early treated; reservoir; viral reservoir ... See more keywords
Intact Proviral DNA Analysis of the Brain Viral Reservoir and Relationship to Neuroinflammation in People with HIV on Suppressive Antiretroviral Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15041009
Abstract: HIV establishes a persistent viral reservoir in the brain despite viral suppression in blood to undetectable levels on antiretroviral therapy (ART). The brain viral reservoir in virally suppressed HIV+ individuals is not well-characterized. In this… read more here.
Keywords: intact proviral; proviral dna; brain; viral reservoir ... See more keywords