Ultrasensitive Immunoassay for Assessing Residual Simian-Tropic HIV in Nonhuman Primate Models of AIDS
Sign Up to like & getrecommendations! Published in 2019 at "AIDS Research and Human Retroviruses"
DOI: 10.1089/aid.2018.0278
Abstract: Abstract Persistence of replication-competent viral reservoirs during infection remains a barrier to HIV cure, despite the ability of combination antiretroviral therapy (cART) to effectively suppress viral replication. Simian-tropic HIV (stHIV) is a minimally chimeric HIV-1… read more here.
Keywords: ultrasensitive immunoassay; hiv; viral reservoirs; simian tropic ... See more keywords
Contextualizing bats as viral reservoirs
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abd4559
Abstract: Preventing zoonotic emergence from bats requires integrative research Coronavirus disease 2019 (COVID-19) is the latest in a distressing tally of viral infections—including Ebola, Nipah, rabies, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome… read more here.
Keywords: viral reservoirs; contextualizing bats; bats viral;
Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01639-19
Abstract: For HIV cure strategies like “kick and kill” to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We… read more here.
Keywords: animal models; preclinical animal; viral reservoirs; penetration ... See more keywords