In vitro and in vivo suppression of SARS‐CoV‐2 replication by a modified, short, cell‐penetrating peptide targeting the C‐terminal domain of the viral spike protein
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28626
Abstract: Peptides are promising therapeutic agents for COVID‐19 because of their specificity, easy synthesis, and ability to be fine‐tuned. We previously demonstrated that a cell‐permeable peptide corresponding to the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)… read more here.
Keywords: cell; spike; replication; terminal domain ... See more keywords
Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2020.114123
Abstract: Abstract Commonly used drugs for treating many conditions are either natural products or derivatives. In silico modelling has identified several natural products including quercetin as potential highly effective disruptors of the initial infection process involving… read more here.
Keywords: cov covid; covid viral; viral spike; natural products ... See more keywords
DeGlyPHER: An Ultrasensitive Method for the Analysis of Viral Spike N-Glycoforms.
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DOI: 10.1021/acs.analchem.1c03059
Abstract: Viruses can evade the host immune system by displaying numerous glycans on their surface "spike-proteins" that cover immune epitopes. We have developed an ultrasensitive "single-pot" method to assess glycan occupancy and the extent of glycan… read more here.
Keywords: deglypher ultrasensitive; viral spike; analysis; method ... See more keywords
SARS‐CoV‐2 viral spike G614 mutation exhibits higher case fatality rate
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DOI: 10.1111/ijcp.13525
Abstract: The COVID‐19 pandemic is caused by infection with the SARS‐CoV‐2 virus. The major mutation detected to date in the SARS‐CoV‐2 viral envelope spike protein, which is responsible for virus attachment to the host and is… read more here.
Keywords: viral spike; cov viral; sars cov; mutation ... See more keywords
A dynamic viral spike
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.369.6511.1579-c
Abstract: Coronavirus Efforts to protect human cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the trimeric spike (S) protein. Several structures have shown a stabilized ectodomain of the spike in its prefusion… read more here.
Keywords: science; dynamic viral; microscopy; viral spike ... See more keywords
Molecular Mimicry of the Viral Spike in the SARS-CoV-2 Vaccine Possibly Triggers Transient Dysregulation of ACE2, Leading to Vascular and Coagulation Dysfunction Similar to SARS-CoV-2 Infection
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15051045
Abstract: The benefits of SARS-CoV-2 spike mRNA vaccines are well known, including a significant decline in COVID-19 morbidity and a decrease in the mortality rate of SARS-CoV-2 infected persons. However, pharmacovigilance studies have revealed the existence… read more here.
Keywords: infection; viral spike; vaccine; molecular mimicry ... See more keywords