HCV-2a NS5A downregulates viral translation predominantly through domain I.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.177
Abstract: Hepatitis C virus (HCV) non-structural protein NS5A is a multifunctional protein with critical roles in viral replication and assembly. We previously showed that HCV-1b NS5A downregulates viral translation only in the presence of the poly(U/UC)… read more here.
Keywords: ns5a downregulates; downregulates viral; translation; hcv ns5a ... See more keywords
Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117198119
Abstract: Significance The COVID-19 pandemic and the ever-evolving variants of SARS-CoV-2 are taking a toll on human health. Despite the successful rollout of vaccines, effective therapies are still urgently needed. Our studies here showing that Nsp1… read more here.
Keywords: sars cov; stem loop; viral translation; cov utr ... See more keywords
Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein–mediated viral translation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.142805
Abstract: Diabetes mellitus (DM) is highly comorbid with severe dengue diseases; however, the underlying mechanisms are unclear. Patients with DM have a 1.61-fold increased risk of developing dengue hemorrhagic fever. In search of host factors involved… read more here.
Keywords: viral translation; infection; poly binding; dengue virus ... See more keywords
CMPK2 restricts Zika virus replication by inhibiting viral translation
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011286
Abstract: Flaviviruses continue to emerge as global health threats. There are currently no Food and Drug Administration (FDA) approved antiviral treatments for flaviviral infections. Therefore, there is a pressing need to identify host and viral factors… read more here.
Keywords: viral translation; replication; restricts zika; cmpk2 ... See more keywords