A pan-genotype hepatitis C virus viral vector vaccine generates T-cells and neutralizing antibodies in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32470
Abstract: BACKGROUND & AIMS A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization (WHO) elimination targets. Neutralizing antibodies (nAb), CD4+ and CD8+ T-cells are associated with spontaneous clearance of… read more here.
Keywords: viral vector; pan genotype; hcv; neutralizing antibodies ... See more keywords
Adeno-associated viral vector gene therapy: Challenges for the paediatric hepatologist.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of pediatric gastroenterology and nutrition"
DOI: 10.1002/jpn3.12326
Abstract: Hepatoxicity associated with recombinant adeno-associated virus gene therapy is being increasingly encountered by hepatologists in tertiary and quaternary referral units due to the recent increase of these therapies for neuromuscular and haematological disorders. The challenges… read more here.
Keywords: adeno associated; viral vector; associated viral; gene therapy ... See more keywords
Evaluation of Innate Lymphoid Cells and Dendritic Cells Following Viral Vector Vaccination.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2168-4_8
Abstract: Recently, we have shown that fate of a vaccine is determined by the cytokine milieu in the innate immune compartment at the early stage of vaccination. Specifically, 24 h post-delivery, level of innate lymphoid cell type… read more here.
Keywords: innate; viral vector; vaccination; innate lymphoid ... See more keywords
Virus-Induced Gene Silencing (VIGS) and Foreign Gene Expression in Pisum sativum L. Using the "One-Step" Bean pod mottle virus (BPMV) Viral Vector.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7231-9_23
Abstract: Plant viral vectors have been developed to facilitate gene function studies especially in plant species not amenable to traditional mutational or transgenic modifications. In the Fabaceae plant family, the most widely used viral vector is… read more here.
Keywords: bean pod; viral vector; pod mottle; gene ... See more keywords
Development of a BoHV-4 viral vector expressing tgD of BoHV-1 and evaluation of its immunogenicity in mouse model
Sign Up to like & getrecommendations! Published in 2021 at "Brazilian Journal of Microbiology"
DOI: 10.1007/s42770-021-00525-z
Abstract: In recent years, Bovine herpesvirus 4 (BoHV-4) has emerged as an attractive gene delivery viral vector, mainly for vaccination purposes in the veterinary field. In the present study, a new infectious clone of the BoHV-4… read more here.
Keywords: tgd; vector; viral vector; bohv ... See more keywords
Halloysite nanotubes-carbon dots hybrids multifunctional nanocarrier with positive cell target ability as a potential non-viral vector for oral gene therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2019.05.062
Abstract: HYPOTHESIS The use of non-viral vectors for gene therapy is hindered by their lower transfection efficiency and their lacking of self-track ability. EXPERIMENTS This study aims to investigate the biological properties of halloysite nanotubes-carbon dots… read more here.
Keywords: non viral; viral vector; gene therapy; microscopy ... See more keywords
Platform for the growth and propogation of HEK293 cells and adenovirus viral vector amplification
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.03.332
Abstract: Background & Aim Industrialization of viral vector production for gene therapy applications demands consistent processes utilizing robust production platforms and raw materials that can meet quality standards and regulatory compliance. Typical vector production schemes involve… read more here.
Keywords: bioreactor; growth; viral vector; amplification ... See more keywords
The Brighton Collaboration standardized template for collection of key information for benefit-risk assessment of viral vector vaccines
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.08.009
Abstract: Many of the vaccines under development for COVID-19 involve the use of viral vectors. The Brighton Collaboration Benefit-Risk Assessment of Vaccines by Technology (BRAVATO, formerly the Viral Vector Vaccine Safety Working Group, V3SWG) working group… read more here.
Keywords: vector; viral vector; risk assessment; vector vaccines ... See more keywords
Cutaneous T-cell lymphoma (CTCL) exacerbation after viral vector COVID-19 vaccination
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Cancer"
DOI: 10.1016/s0959-8049(21)00755-3
Abstract: Introduction: We are living an ongoing global COVID-19 pandemic associated with a considerable number of fatal cases worldwide. Cancer patients seem to exhibit exacerbated conditions and higher mortality rates. Vaccines are a promising solution to… read more here.
Keywords: cutaneous cell; viral vector; covid; cell ... See more keywords
Identifying Viral Vector Characteristics by Nanopore Sensing.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.4c01888
Abstract: Using viral vectors as gene delivery vehicles for gene therapy necessitates their quality control. Here, we report on nanopore sensing for nondestructively inspecting genomes inside the nanoscale cargoes at the single-molecule level. Using ionic current… read more here.
Keywords: identifying viral; vector characteristics; gene; characteristics nanopore ... See more keywords
Unique IL-13Rα2/STAT3 mediated IL-13 regulation detected in lung conventional dendritic cells, 24 h post viral vector vaccination
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-57815-z
Abstract: This study demonstrates that 24 h following viral vector-based vaccination IL-13Rα2 functions as a master sensor on conventional dendritic cells (cDCs), abetted by high protein stability coupled with minimal mRNA expression, to rapidly regulate DC mediated… read more here.
Keywords: vector; viral vector; stat3; conventional dendritic ... See more keywords