Characterization and epitope mapping of a panel of monoclonal antibodies against HIV‐1 matrix protein
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1662
Abstract: The HIV‐1 Gag precursor protein (p55) is the main structural protein comprising the matrix (MA/p17), capsid (CA/p24), and nucleocapsid (NC/p7) proteins, and is uniquely responsible for virion assembly within the virus life cycle. The MA… read more here.
Keywords: protein; virion; monoclonal antibodies; panel monoclonal ... See more keywords
An E. coli‐produced single‐chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.12.019
Abstract: ABSTRACT Hepatitis B virus (HBV) envelopes as well as empty subviral particles carry in their lipid membranes the small (S), middle (M), and large (L) surface proteins, collectively known as hepatitis B surface antigen (HBsAg).… read more here.
Keywords: virion; g12 scfv; secretion; hepatitis ... See more keywords
Collective properties of viral infectivity.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2018.06.001
Abstract: Individual virions typically fail to infect cells. Such decoupling between virions and infectious units is most evident in multicomponent and other segmented viruses, but is also frequent in non-segmented viruses. Despite being a well-known observation,… read more here.
Keywords: virion; properties viral; virology; collective properties ... See more keywords
Primary Envelopment of the Herpes Simplex 1 Virion
Sign Up to like & getrecommendations! Published in 2017 at "Microscopy and Microanalysis"
DOI: 10.1017/s143192761700678x
Abstract: Herpes simplex virus type 1 (HSV-1), a typical herpesvirus, initially assembles in the nucleus of the infected cell, producing a procapsid, 125 nm in diameter, conforming to icosahedral symmetry. The procapsid is then packaged with… read more here.
Keywords: virion; envelopment herpes; primary envelopment; herpes simplex ... See more keywords
Virion-associated polyamines transmit with bunyaviruses to maintain infectivity and promote entry.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00402
Abstract: Viruses require host cell metabolites to productively infect, and the mechanisms by which viruses usurp these molecules is diverse. One group of cellular metabolites important in virus infection is the polyamines, small positively charged molecules… read more here.
Keywords: virion; maintain infectivity; associated polyamines; virion associated ... See more keywords
Measuring Ligand Binding Kinetics to Membrane Proteins Using Virion Nano-oscillators.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b07461
Abstract: Membrane proteins play vital roles in cellular signaling processes and serve as the most popular drug targets. A key task in studying cellular functions and developing drugs is to measure the binding kinetics of ligands… read more here.
Keywords: virion; membrane proteins; ligand binding; binding kinetics ... See more keywords
The architecture of the SARS-CoV-2 RNA genome inside virion
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22785-x
Abstract: SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion remains unknown. To fill the knowledge gap and… read more here.
Keywords: virion; cov rna; structure; sars cov ... See more keywords
SARS-CoV-2 requires acidic pH to infect cells
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209514119
Abstract: SARS-CoV-2 cell entry starts with membrane attachment and ends with spike-protein (S) catalyzed membrane fusion depending on two cleavage steps, one usually by furin in producing cells and the second by TMPRSS2 on target cells.… read more here.
Keywords: cell; fusion; cov requires; virion ... See more keywords
Maturation of the matrix and viral membrane of HIV-1
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abe6821
Abstract: Structural changes in HIV maturation Nascent HIV particles assemble at the plasma membrane of an infected cell and bud into a membrane-enveloped, immature virion. Assembly and budding are driven by a polyprotein called Gag, which… read more here.
Keywords: virion; hiv; viral membrane; maturation ... See more keywords
Rotavirus VP4 Epitope of a Broadly Neutralizing Human Antibody Defined by Its Structure Bound with an Attenuated-Strain Virion
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00627-22
Abstract: Rotavirus live-attenuated vaccines generate broadly heterotypic protection, and B-cells isolated from adults encode antibodies that are broadly protective in mice. Determining the structural and mechanistic basis of broad protection can contribute to understanding the current… read more here.
Keywords: protection; structure; virion; rotavirus ... See more keywords
Determination of Critical Requirements for Classical Swine Fever Virus NS2-3-Independent Virion Formation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.00679-19
Abstract: For Flaviviridae members, the nonstructural proteins are essential for virion formation and thus exert a dual role in RNA replication and virion morphogenesis. However, it remains unclear how these proteins are functionalized for either process.… read more here.
Keywords: virion morphogenesis; virion; ns2 independent; virion formation ... See more keywords