Understanding the Risk of Human Immunodeficiency Virus (HIV) Virologic Failure in the Era of Undetectable Equals Untransmittable
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DOI: 10.1007/s10461-020-03154-z
Abstract: The “Undetectable = Untransmittable” campaign indicates that persons living with Human Immunodeficiency Virus (HIV) who maintain a suppressed viral load cannot sexually transmit the virus. However, there is little knowledge of the percent of individuals at a… read more here.
Keywords: human immunodeficiency; risk; hiv; virologic failure ... See more keywords
HCV Viral Load Greater Than 1000 IU/ml at Time of Virologic Failure in Direct-Acting Antiviral-Treated Patients
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DOI: 10.1007/s12325-021-01647-4
Abstract: One of the remaining barriers to reaching WHO elimination targets of achieving global hepatitis C (HCV) cure is a lack of an established lower limit of detection (LLOD) to confirm cure post-treatment in near-patient technologies.… read more here.
Keywords: expedition; virologic failure; time; hcv rna ... See more keywords
Virologic Outcomes Among ART-Naïve Individuals Initiating Dolutegravir, Elvitegravir, Raltegravir or Darunavir: An Observational Study
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DOI: 10.1007/s40121-019-00274-5
Abstract: Introduction Dolutegravir (DTG), Elvitegravir (EVG), Raltegravir (RAL) and Darunavir (DRV) are commonly prescribed core agents for antiretroviral therapy (ART), and a need exists to compare their clinical effectiveness, as defined by virologic failure risks in… read more here.
Keywords: ral drv; dtg; virologic failure; drv ... See more keywords
Management of Virologic Failure and HIV Drug Resistance
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DOI: 10.1016/j.idc.2019.05.004
Abstract: Approximately 20% of people with HIV in the United States prescribed antiretroviral therapy are not virally suppressed. Thus, optimal management of virologic failure has a critical role in the ability to improve viral suppression rates… read more here.
Keywords: hiv drug; virologic failure; resistance; failure ... See more keywords
Virologic failure and switch to second-line antiretroviral therapy in children with HIV in Lilongwe, Malawi: an observational cohort study.
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DOI: 10.1093/trstmh/trz087
Abstract: BACKGROUND As routine viral load testing among HIV-infected individuals on antiretroviral therapy (ART) expands, virologic failure (VF) among children in developing countries remains poorly understood. We assessed the rate of VF, the proportion failing who… read more here.
Keywords: antiretroviral therapy; line; virologic failure; art ... See more keywords
Impact of previous HIV resistance and virologic failures on virologic outcome following a switch to dolutegravir with 2 NRTIs among people living with HIV
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DOI: 10.1097/md.0000000000023335
Abstract: Supplemental Digital Content is available in the text Abstract There is uncertainty regarding the potential virologic outcome associated with a change in antiretroviral therapy (ARV) among PLHIV who had previous documented virologic failure or who… read more here.
Keywords: switch; therapy; dolutegravir nrtis; virologic failure ... See more keywords
Effectiveness of integrase strand transfer inhibitors among treatment-experienced patients in a clinical setting
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DOI: 10.1097/qad.0000000000002194
Abstract: Objective: Characterize virologic and immunologic outcomes of INSTI-based antiretroviral therapy (ART) in experienced patients with and without virologic failure. Design: Prospective clinical cohort. Methods: ART-experienced, INSTI-naive participants in the University of North Carolina Center for… read more here.
Keywords: virologic failure; viral load; baseline viral; patients baseline ... See more keywords
HIV Virologic Failure among Patients with Persistent Low-Level Viremia in Nairobi, Kenya: It Is Time to Review the >1000 Virologic Failure Threshold
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DOI: 10.1155/2023/8961372
Abstract: Persistent low-level viremia (PLLV) of 200-999 copies/ml has been reported as a risk factor for HIV virologic failure (VF). This retrospective study was aimed at characterizing patients with PLLV, determining factors associated with VF, and… read more here.
Keywords: failure; 999 copies; low level; 200 999 ... See more keywords
Dolutegravir/rilpivirine 2-drug regimen comparable to commonly prescribed 3-drug regimens up to 18-months in a real-world setting
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DOI: 10.1177/13596535211073235
Abstract: Background This study compared the effectiveness and durability of DTG/RPV with commonly prescribed 3-drug regimens (3-DR) in people living with HIV (PLWH) in a real-world setting. Methods Antiretroviral therapy (ART)-experienced, virologically suppressed PLWH who initiated… read more here.
Keywords: virologic failure; drug; real world; dtg rpv ... See more keywords
Antiretroviral therapy adherence patterns, virological suppression, and emergence of drug resistance: A nested case–control study from Uganda and South Africa
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DOI: 10.1177/13596535221114822
Abstract: Background Relationships between distinct antiretroviral therapy (ART) adherence patterns and risk of drug resistance are not well understood. Methods We conducted a nested case–control analysis within a longitudinal cohort study of individuals initiating efavirenz-based ART.… read more here.
Keywords: virologic failure; resistance; adherence; drug resistance ... See more keywords
Comparison of atazanavir/ritonavir and darunavir/ritonavir based antiretroviral therapy for antiretroviral naïve patients
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DOI: 10.1186/s12879-017-2379-8
Abstract: BackgroundAtazanavir/ritonavir and darunavir/ritonavir are common protease inhibitor-based regimens for treating patients with HIV. Studies comparing these drugs in clinical practice are lacking.MethodsWe conducted a retrospective cohort study of antiretroviral naïve participants in the Canadian Observational… read more here.
Keywords: virologic failure; atazanavir ritonavir; darunavir ritonavir; ritonavir ... See more keywords