Oncolytic Virotherapy by HSV.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-7230-7_4
Abstract: Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type… read more here.
Keywords: generation oncolytic; virotherapy hsv; virotherapy; oncolytic viruses ... See more keywords
Comprehensive characterization of tumor immune landscape following oncolytic virotherapy by single-cell RNA sequencing
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-03084-2
Abstract: An important mechanism of oncolytic virotherapy in ameliorating cancer immunotherapy is by inducing significant changes in the immune landscape in the tumor microenvironment (TME). Despite this notion and the potential therapeutic implications, a comprehensive analysis… read more here.
Keywords: immune landscape; single cell; oncolytic virotherapy; virotherapy ... See more keywords
A mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative treatment against a glioma
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DOI: 10.1007/s10910-019-01084-3
Abstract: In this paper, we propose a mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative to treatment of a glioma. The main idea is to incorporate the virotherapy after the first or second… read more here.
Keywords: oncolytic virotherapy; combines chemotherapy; chemotherapy oncolytic; virotherapy ... See more keywords
Natural Killer Cells Recruitment in Oncolytic Virotherapy: A Mathematical Model.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of mathematical biology"
DOI: 10.1007/s11538-021-00903-6
Abstract: In this paper, we investigate how natural killer (NK) cell recruitment to the tumor microenvironment (TME) affects oncolytic virotherapy. NK cells play a major role against viral infections. They are, however, known to induce early… read more here.
Keywords: natural killer; mathematical model; oncolytic virotherapy; virotherapy ... See more keywords
ECHO-7 oncolytic virus Rigvir® in an adjuvant setting for stage I uveal melanoma; A retrospective case report
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DOI: 10.1016/j.ajoc.2020.100615
Abstract: Purpose To describe a case of choroidal melanoma treated with Rigvir® virotherapy in an adjuvant setting. Observations A female patient born in 1956 presented with a small choroidal melanoma in October 2007. 34 months after… read more here.
Keywords: adjuvant setting; virotherapy; uveal melanoma; case ... See more keywords
716 Cell-based virotherapy for targeting cancers
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0716
Abstract: Background Oncolytic virotherapy has been recognized as a promising new therapy for cancer for decades but only few viruses have been approved worldwide. The therapeutic potential of oncolytic viruses can be severely restricted by innate… read more here.
Keywords: virotherapy; cell based; cancer; cell ... See more keywords
Virotherapy combined with anti-PD-1 transiently reshapes the tumor immune environment and induces anti-tumor immunity in a preclinical PDAC model
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1096162
Abstract: Introduction Pancreatic ductal adenocarcinoma (PDAC) is largely refractory to cancer immunotherapy with PD-1 immune checkpoint blockade (ICB). Oncolytic virotherapy has been shown to synergize with ICB. In this work, we investigated the combination of anti-PD-1… read more here.
Keywords: tumor immunity; anti tumor; immunity; virotherapy ... See more keywords
Oncolytic Virotherapy in Peritoneal Metastasis Gastric Cancer: The Challenges and Achievements
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.835300
Abstract: Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer death globally. Although the mortality rate in some parts of the world, such as East Asia, is still high,… read more here.
Keywords: cancer; virotherapy; peritoneal metastasis; metastasis ... See more keywords
Design Strategies and Precautions for Using Vaccinia Virus in Tumor Virotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10091552
Abstract: Oncolytic virotherapy has emerged as a novel form of cancer immunotherapy. Oncolytic viruses (OVs) can directly infect and lyse the tumor cells, and modulate the beneficial immune microenvironment. Vaccinia virus (VACV) is a promising oncolytic… read more here.
Keywords: tumor; vaccinia virus; cancer; virotherapy ... See more keywords