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Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01336
Abstract: Chemical inhibition of epigenetic regulatory proteins BrdT and Brd4 is emerging as a promising therapeutic strategy in contraception, cancer, and heart disease. We report an easily synthesized dihydropyridopyrimidine pan-BET inhibitor scaffold, which was uncovered via…
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Keywords:
bet bromodomain;
virtual screen;
screen;
bromodomain inhibitors ... See more keywords
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Published in 2020 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.001203
Abstract: Introduction. The emergence of SARS-CoV-2 has taken humanity off guard. Following an outbreak of SARS-CoV in 2002, and MERS-CoV about 10 years later, SARS-CoV-2 is the third coronavirus in less than 20 years to cross the species…
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Keywords:
rna dependent;
virtual screen;
rna;
rna polymerase ... See more keywords