A Smart Hydrogel with Anti-biofilm and Anti-virulence Activities to Treat P. aeruginosa Infections.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202200299
Abstract: Biofilm is the main culprit of refractory infections and seriously threaten to the human health. Here, a smart hydrogel consisted of norspermidine, aminoglycosides and oxidized polysaccharide was prepared via the formation of acid-labile imine linkage… read more here.
Keywords: virulence; smart hydrogel; biofilm; hydrogel anti ... See more keywords
A-to-I RNA Editing in Klebsiella pneumoniae Regulates Quorum Sensing and Affects Cell Growth and Virulence.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206056
Abstract: Millions of adenosine (A) to inosine (I) RNA editing events are reported and well-studied in eukaryotes; however, many features and functions remain unclear in prokaryotes. By combining PacBio Sequel, Illumina whole-genome sequencing, and RNA Sequencing… read more here.
Keywords: rna editing; klebsiella pneumoniae; rna; virulence ... See more keywords
Tailored Phenyl Esters Inhibit ClpXP and Attenuate Staphylococcus aureus α‐Hemolysin Secretion
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200253
Abstract: Novel strategies against multidrug‐resistant bacteria are urgently needed in order to overcome the current silent pandemic. Manipulation of toxin production in pathogenic species serves as a promising approach to attenuate virulence and prevent infections. In… read more here.
Keywords: phenyl esters; attenuate; tailored phenyl; staphylococcus aureus ... See more keywords
Repurposing Nitroimidazoles: A New Frontier in Combatting Bacterial Virulence and Quorum Sensing via In Silico, In Vitro, and In Vivo Insights
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70101
Abstract: The global antibiotic resistance crisis demands innovative strategies targeting bacterial virulence rather than survival. Quorum sensing (QS), a key regulator of virulence and biofilm formation, offers a promising avenue to mitigate resistance by disarming pathogens… read more here.
Keywords: vivo; silico vitro; virulence; repurposing nitroimidazoles ... See more keywords
Resource asynchrony and landscape homogenization as drivers of virulence evolution: The case of a directly transmitted disease in a social host
Sign Up to like & getrecommendations! Published in 2024 at "Ecology and Evolution"
DOI: 10.1002/ece3.11065
Abstract: Abstract Throughout the last decades, the emergence of zoonotic diseases and the frequency of disease outbreaks have increased substantially, fuelled by habitat encroachment and vectors overlapping with more hosts due to global change. The virulence… read more here.
Keywords: evolution; host; homogenization; virulence ... See more keywords
Molecular epidemiology and virulence factors of methicillin‐resistant Staphylococcus aureus isolated from patients with bacteremia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23077
Abstract: The various virulence factors of methicillin‐resistant Staphylococcus aureus bacteremia (MRSAB) are associated with a high mortality rate worldwide. Further studies are warranted to confirm the significant relationship between the strains and virulence genes. Here, we… read more here.
Keywords: virulence; resistant staphylococcus; virulence factors; methicillin resistant ... See more keywords
Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in gram‐negative bacteria
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70032
Abstract: Abstract CprA is a short‐chain dehydrogenase/reductase (SDR) that contributes to resistance against colistin and antimicrobial peptides. The cprA gene is conserved across Pseudomonas aeruginosa clades and its expression is directly regulated by the two‐component system… read more here.
Keywords: new family; outer membrane; gram negative; virulence ... See more keywords
Influenza A virus PB1‐F2 protein: An ambivalent innate immune modulator and virulence factor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4mr0320-206r
Abstract: Influenza A virus (IAV) causes not only seasonal respiratory illness, but also outbreaks of more severe disease and pandemics when novel strains emerge as a result of reassortment or interspecies transmission. PB1‐F2 is an IAV… read more here.
Keywords: pb1; ambivalent innate; virulence factor; immune ... See more keywords
Assessing pH‐dependent activities of virulence factors secreted by Candida albicans
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DOI: 10.1002/mbo3.1342
Abstract: Candida albicans is an opportunistic pathogen that can thrive under adverse conditions including suboptimal pH, nutrient scarcity, and low levels of oxygen. Its pathogenicity is associated with the production of virulence factors such as extracellular… read more here.
Keywords: activities virulence; dependent activities; assessing dependent; virulence ... See more keywords
The Rhodococcus equi virulence protein VapA disrupts endolysosome function and stimulates lysosome biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.416
Abstract: Rhodococcus equi (R. equi) is an important pulmonary pathogen in foals that often leads to the death of the horse. The bacterium harbors a virulence plasmid that encodes numerous virulence‐associated proteins (Vaps) including VapA that… read more here.
Keywords: virulence; rhodococcus equi; lysosome biogenesis; function ... See more keywords
Serial passage through resistant and susceptible cucumber cultivars affects the virulence of Fusarium oxysporum f. sp. cucumerinum
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DOI: 10.1002/mbo3.641
Abstract: Fusarium oxysporum f. sp. cucumerinum (Foc) is the causal pathogen of cucumber Fusarium wilt resulting in losses to cucumber production. To investigate the effects of the selective pressures of host plants on the virulence of… read more here.
Keywords: cucumber; fusarium; virulence; oxysporum ... See more keywords