Is the Site of Influenza Virus Assembly and Budding Enriched with Cholesterol and Sphingolipids
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1727
Abstract: The observation that the influenza viral envelope is enriched with cholesterol and sphingolipids contributed to the hypothesis that the influenza virus assembles and bud from cholesterol- and sphingolipid-enriched domains in the plasma membrane. The formation… read more here.
Keywords: cholesterol sphingolipids; enriched cholesterol; cholesterol; virus assembly ... See more keywords
A structural view of the SARS-CoV-2 virus and its assembly
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Virology"
DOI: 10.1016/j.coviro.2021.11.011
Abstract: The SARS-CoV-2 pandemic that struck in 2019 has left the world crippled with hundreds of millions of cases and millions of people dead. During this time, we have seen unprecedented support and collaboration amongst scientists… read more here.
Keywords: sars cov; cov virus; view sars; virus assembly ... See more keywords
Virus Assembly Pathways Inside a Host Cell.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c06335
Abstract: Simple RNA viruses self-assemble spontaneously and encapsulate their genome into a shell called the capsid. This process is mainly driven by the attractive electrostatics interaction between the positive charges on capsid proteins and the negative… read more here.
Keywords: host cell; virus; virus assembly;
One step at a time: new insights into double-stranded ribonucleic acid virus assembly
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01949-3
Abstract: In a recent paper published in Cell , Xia et al. 1 carried out 3D reconstructions of Blue Tongue Virus (BTV) particles and their assembly intermediates using a combination of cellular cryo-electron tomography (Cryo-ET) and… read more here.
Keywords: double stranded; stranded ribonucleic; virus assembly; virus ... See more keywords
Structures of a large prolate virus capsid in unexpanded and expanded states generate insights into the icosahedral virus assembly
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203272119
Abstract: Significance Virus assembly occurs by repeated association of tiny building blocks, the capsid protein subunits. The assembled structures are highly dynamic and undergo maturation transformations, ultimately generating an infectious virion particle. We describe, at near-atomic… read more here.
Keywords: icosahedral virus; large prolate; virus assembly; capsid ... See more keywords
NS5A domain I antagonises PKR to facilitate the assembly of infectious hepatitis C virus particles
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1101/2022.08.22.504903
Abstract: Hepatitis C virus NS5A is a multifunctional phosphoprotein comprised of three domains (DI, DII and DIII). DI and DII have been shown to function in genome replication, whereas DIII has a role in virus assembly.… read more here.
Keywords: pkr; assembly infectious; virus particles; virus assembly ... See more keywords
Spatiotemporal coordination of reovirus peripheral core replication to perinuclear whole virus assembly
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1013238
Abstract: Reoviruses coordinate their replication and assembly through intricate spatial and temporal compartmentalization within host cells. In this study, we elucidate the dynamics of mammalian orthoreovirus (reovirus) core replication and viral particle assembly. Using high-resolution immunofluorescence… read more here.
Keywords: replication; core; core replication; virus assembly ... See more keywords