Universal label-free in-process quantification of influenza virus-like particles.
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology journal"
DOI: 10.1002/biot.201700031
Abstract: Virus-like particles (VLPs) are becoming established as vaccines, in particular for influenza pandemics, increasing the interest in the development of VLPs manufacturing bioprocess. However, for complex VLPs, the analytical tools used for quantification are not… read more here.
Keywords: virus like; influenza; process; like particles ... See more keywords
Differential N- and O-glycosylation signatures of HIV-1 Gag virus-like particles and coproduced extracellular vesicles.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28051
Abstract: HIV-1 virus-like particles (VLPs) are nanostructures derived from the self-assembly and cell budding of Gag polyprotein. Mimicking the native structure of the virus and being non-infectious, they represent promising candidates for the development of new… read more here.
Keywords: coproduced extracellular; virus like; glycosylation; extracellular vesicles ... See more keywords
Process Monitoring Framework for Cross-flow Diafiltration-based Virus-like Particle Disassembly: Tracing Product Properties and Filtration Performance.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28063
Abstract: Virus-like particles (VLPs) are an emerging biopharmaceutical modality with great potential as a platform technology. VLPs can be applied as gene therapy vectors and prophylactic or therapeutic vaccines. For non-enveloped VLPs, recombinant production of the… read more here.
Keywords: product; virus like; diafiltration based; process ... See more keywords
An integrated and continuous downstream process for microbial virus‐like particle vaccine biomanufacture
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28118
Abstract: In this study, we present the first integrated and continuous downstream process for the production of microbial virus‐like particle vaccines. Modular murine polyomavirus major capsid VP1 with integrated J8 antigen was used as a model… read more here.
Keywords: continuous downstream; process; downstream process; integrated continuous ... See more keywords
Downstream process design for Gag HIV-1 based virus-like particles.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28419
Abstract: Virus-like particles-based vaccines have been gaining interest in recent years. The manufacturing of these particles includes their production by cell culture followed by their purification to meet the requirements of its final use. The presence… read more here.
Keywords: purification; step; like particles; process ... See more keywords
Development of virus‐like particles‐based vaccines against coronaviruses
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3292
Abstract: Severe acute respiratory syndrome coronavirus (SARS‐CoV), Middle East respiratory syndrome coronavirus (MERS‐CoV), and the current severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are the most impactful coronaviruses in human history, especially the latter, which brings… read more here.
Keywords: based vaccines; development; vaccines coronaviruses; virus like ... See more keywords
Impact of Peptide Sequences on Their Structure and Function: Mimicking of Virus‐Like Nanoparticles for Nucleic Acid Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200519
Abstract: We rationally designed a series of amphiphilic hepta‐peptides enriched with a chemically conjugated guanidiniocarbonylpyrrole (GCP) unit at the lysine side chain. All peptides are composed of polar (GCP) and non‐polar (cyclohexyl alanine) residues but differ… read more here.
Keywords: impact peptide; peptide sequences; nucleic acid; sequences structure ... See more keywords
All the small things: How virus‐like particles and liposomes modulate allergic immune responses
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847810
Abstract: Recent years have seen a dramatic increase in the range of applications of virus‐like nanoparticle (VNP)‐ and liposome‐based antigen delivery systems for the treatment of allergies. These platforms rely on a growing number of inert… read more here.
Keywords: things virus; small things; liposomes modulate; virus like ... See more keywords
Polysorbate 80 and Histidine Quantitative Analysis by NMR in the presence of Virus-like Particles.
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DOI: 10.1002/elps.202100189
Abstract: Polysorbate-80 (PS80) and histidine are common excipients in vaccine and therapeutic protein formulation. A simple quantitative NMR method to measure both PS80 and histidine in human papillomavirus (HPV) virus-like particle (VLP) vaccine for aqueous and… read more here.
Keywords: polysorbate histidine; nmr method; ps80; virus like ... See more keywords
Long‐time scale simulations of virus‐like particles from three human‐norovirus strains
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.27087
Abstract: The dynamics of the virus like particles (VLPs) corresponding to the GII.4 Houston, GII.2 SMV, and GI.1 Norwalk strains of human noroviruses (HuNoV) that cause gastroenteritis was investigated by means of long‐time (about 30 μs… read more here.
Keywords: like particles; long time; scale simulations; virus like ... See more keywords
Marburg virus‐like particles produced in insect cells induce neutralizing antibodies in rhesus macaques
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24832
Abstract: Marburg virus (MARV), which is one of the most virulent agents in the world, causes lethal haemorrhagic fever in humans and nonhuman primates (NHPs) with a mortality rate of up to 90%. Currently, there is… read more here.
Keywords: marburg virus; marv; virus like; rhesus macaques ... See more keywords