Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs
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DOI: 10.1002/ardp.202200518
Abstract: Cyclization of small molecules is a widely applied strategy in drug design for ligand optimization to improve affinity, as it eliminates the putative need for structural preorganization of the ligand before binding, or to improve… read more here.
Keywords: virus ns2b; macrocyclic zika; zika virus; protease inhibitor ... See more keywords
Synthesis, X-ray crystallographic study, pharmacology and docking of hydrazinyl thiazolyl coumarins as dengue virus NS2B/NS3 serine protease inhibitors
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DOI: 10.1007/s00044-018-2179-8
Abstract: A series of total twenty-one thiazole-coumarin derivatives 7a-u, linked via hydrazine linkage were synthesized through Hantzsch cyclisation. Out of twenty-one derivatives, fourteen derivatives viz. 7b-d, 7g, 7i-k, 7n and 7p-u are the novel derivatives. The… read more here.
Keywords: dengue virus; ns3 serine; virus ns2b; ns2b ns3 ... See more keywords