Inhibitors of Influenza A Virus Polymerase.
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.7b00265
Abstract: The propensity of influenza virus to develop resistance to commonly prescribed drugs highlights the need for continuing development of new therapeutics. Biological and structural investigations of the enzymatic and interaction domains among influenza A virus… read more here.
Keywords: influenza virus; inhibitors influenza; polymerase; virus polymerase ... See more keywords
Bilobetin, a novel small molecule inhibitor targeting influenza virus polymerase acidic (PA) endonuclease was screened from plant extracts.
Sign Up to like & getrecommendations! Published in 2020 at "Natural product research"
DOI: 10.1080/14786419.2020.1808636
Abstract: The influenza A virus polymerase acidic (PA) endonuclease is an attractive target for anti-influenza drug development. In this study, plant extracts were used to screen the inhibitor against the PA endonuclease and its mutant. In… read more here.
Keywords: endonuclease; polymerase acidic; influenza virus; virus polymerase ... See more keywords
Elucidating the Interactions between Influenza Virus Polymerase and Host Factor ANP32A
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.01353-19
Abstract: Successful zoonotic transmission of influenza A virus into humans can lead to pandemics in an immunologically naive population. Host-encoded ANP32A proteins are required to support influenza A virus polymerase activity, and species differences in ANP32A… read more here.
Keywords: virus polymerase; influenza virus; anp32a proteins; polymerase ... See more keywords
Influenza A virus polymerase acidic protein E23G/K substitutions weaken key baloxavir drug-binding contacts with minimal impact on replication and transmission
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010698
Abstract: Baloxavir marboxil (BXM) is approved for treating uncomplicated influenza. The active metabolite baloxavir acid (BXA) inhibits cap-dependent endonuclease activity of the influenza virus polymerase acidic protein (PA), which is necessary for viral transcription. Treatment-emergent E23G… read more here.
Keywords: e23g substitutions; transmission; influenza virus; bxa ... See more keywords
Focusing on the influenza virus polymerase complex: recent progress in drug discovery and assay development.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666180706112940
Abstract: Influenza viruses are severe human pathogens that pose persistent threat to public health. Each year more people die of influenza virus infection than that of breast cancer. Due to the limited efficacy associated with current… read more here.
Keywords: drug; polymerase; polymerase complex; influenza virus ... See more keywords