Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.11.004
Abstract: ABSTRACT Zika virus (ZIKV), a member of the Flaviviridae family, has recently been linked to abnormal pregnancies, fetal death, microcephaly, and Guillain‐Barré syndrome in humans. Merimepodib (MMPD, VX‐497), a potent inhibitor of inosine‐5′‐monophosphate dehydrogenase (IMPDH),… read more here.
Keywords: inhibitor; emerging viral; virus production; zika virus ... See more keywords
Efficient influenza A virus production in high cell density using the novel porcine suspension cell line PBG.PK2.1.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.04.030
Abstract: Seasonal and pandemic influenza respiratory infections are still a major public health issue. Vaccination is the most efficient way to prevent influenza infection. One option to produce influenza vaccines is cell-culture based virus propagation. Different… read more here.
Keywords: influenza virus; cell; influenza; virus production ... See more keywords
Comparative analysis of the viral interferon regulatory factors of KSHV for their requisite for virus production and inhibition of the type I interferon pathway.
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DOI: 10.1016/j.virol.2019.12.011
Abstract: Unique among human viruses, Kaposi's sarcoma-associated herpesvirus (KSHV) encodes several homologs of cellular interferon regulatory factors (vIRFs). Since KSHV expresses multiple factors that can inhibit interferon (IFN) signaling to promote virus production, it is still… read more here.
Keywords: production; kshv; interferon; production inhibition ... See more keywords
Epstein–Barr virus ncRNA from a nasopharyngeal carcinoma induces an inflammatory response that promotes virus production
Sign Up to like & getrecommendations! Published in 2019 at "Nature Microbiology"
DOI: 10.1038/s41564-019-0546-y
Abstract: The Epstein–Barr virus M81 strain, isolated from a nasopharyngeal carcinoma, induces potent spontaneous virus production in infected B cells. We found that the M81 non-coding Epstein–Barr-encoded RNA EBER2, which carries polymorphisms that are mainly restricted… read more here.
Keywords: m81; epstein barr; barr virus; virus production ... See more keywords