The clinically used serine protease inhibitor nafamostat reduces influenza virus replication and cytokine production in human airway epithelial cells and viral replication in mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26700
Abstract: The effects of the clinically used protease inhibitor nafamostat on influenza virus replication have not been well studied. Primary human tracheal (HTE) and nasal (HNE) epithelial cells were pretreated with nafamostat and infected with the… read more here.
Keywords: influenza virus; epithelial cells; replication; virus replication ... See more keywords
Host Factors Involved in Ebola Virus Replication.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2017_27
Abstract: Ebola virus (EBOV) is a highly pathogenic emerging virus that represents a serious threat to global public health and a major priority for biodefense. The 2014 West African outbreak demonstrated the potential of EBOV to… read more here.
Keywords: host factors; ebola virus; virus replication; host ... See more keywords
Inhibition effects of novel polyketide compound PPQ‐B against influenza A virus replication by interfering with the cellular EGFR pathway
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.04.007
Abstract: Abstract Development of anti‐influenza A virus (IAV) drugs with novel targets and low toxicity is critical for preparedness against influenza outbreaks. In the current study, our results indicated that the novel polyketide compound purpurquinone B… read more here.
Keywords: iav; inhibition; ppq; virus replication ... See more keywords
Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.003
Abstract: Enterovirus D68 (EV-D68) is a medically important respiratory plus-strand RNA virus of children that has been linked to acute flaccid myelitis. We have determined that EV-D68 induces autophagic signaling and membrane formation. Autophagy, a homeostatic degradative… read more here.
Keywords: snare; virus replication; replication; virus ... See more keywords
Mammalian cells use the autophagy process to restrict avian influenza virus replication.
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DOI: 10.1016/j.celrep.2021.109213
Abstract: Host adaptive mutations in the influenza A virus (IAV) PB2 protein are critical for human infection, but their molecular action is not well understood. We observe that when IAV containing avian PB2 infects mammalian cells,… read more here.
Keywords: pb2; virus replication; mammalian cells; influenza virus ... See more keywords
An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.07.009
Abstract: Virulent pathogens often cause the release of host-derived damage-associated molecular patterns (DAMPs) from infected cells. During encounters with immune-evasive viruses that block inflammatory gene expression, preformed DAMPs provide backup inflammatory signals that ensure protective immunity.… read more here.
Keywords: branch signaling; virus replication; evasive virus; signaling pathway ... See more keywords
Muscovy duck reovirus promotes virus replication by inhibiting autophagy-lysosomal degradation pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2020.108945
Abstract: Autophagy plays a momentous role in cellular responses against pathogens. However, the influence of the autophagy machinery on Muscovy duck reovirus (MDRV) infection is not yet confirmed. In this study, it was shown that MDRV… read more here.
Keywords: degradation; virus replication; mdrv infection; replication ... See more keywords
Kaempferol inhibits Pseudorabies virus replication in vitro through regulation of MAPKs and NF-κB signaling pathways
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Integrative Agriculture"
DOI: 10.1016/s2095-3119(20)63477-3
Abstract: Abstract Pseudorabies virus (PRV), in the family Herpesviridae, is a pathogen of Aujeszky's disease, which causes great economic losses to the pig industry. Recent outbreaks of Pseudorabies imply that new control measures are urgently needed.… read more here.
Keywords: signaling pathways; mapks signaling; kaempferol; virus replication ... See more keywords
Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03658-2
Abstract: Autophagy emerges as an essential immunity defense against intracellular pathogens. Here we report that turnip mosaic virus (TuMV) infection activates autophagy in plants and that Beclin1 (ATG6), a core component of autophagy, inhibits virus replication.… read more here.
Keywords: degradation; beclin1; infection; beclin1 restricts ... See more keywords
Santin inhibits influenza A virus replication through regulating MAPKs and NF-κB pathways
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2018.1520221
Abstract: Abstract Influenza A virus (IAV) causes high morbidity and significant mortality worldwide. Given the limitations of existing vaccination and antiviral drugs, it is urgent to develop new anti-influenza drugs. Flavonoids are natural polyphenolic compounds with… read more here.
Keywords: inhibits influenza; santin inhibits; virus replication; replication regulating ... See more keywords
Regulation of Autophagy by Hepatitis C Virus for Its Replication.
Sign Up to like & getrecommendations! Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2017.4115
Abstract: Macroautophagy, hereafter autophagy, is a catabolic process that is important for maintaining cellular homeostasis. It can also be used by cells to remove intracellular microbial pathogens. However, the studies on hepatitis C virus (HCV) in… read more here.
Keywords: regulation autophagy; virus replication; hepatitis virus; autophagy hepatitis ... See more keywords