Rapid Manufacture and Isolation of Highly Viable Interferon-γ Expressing Virus-Specific T Cells: Validation Results for the Virus-Specific Cytotoxic T-Lymphocyte Consortium for Refractory EBV, CMV, and Adenovirus Infections
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.589
Abstract: Background Children and young adults who develop treatment-refractory infection with EBV, CMV, and/or adenovirus (AdV) after allogeneic hematopoietic stem cell transplant (allo-HSCT) have a dismal prognosis (≥90% mortality). Adoptive transfer of ex-vivo expanded virus-specific cytotoxic… read more here.
Keywords: specific cytotoxic; cmv adenovirus; virus specific; specific cells ... See more keywords
The avidity of cross-reactive virus-specific T cells for their viral and allogeneic epitopes is variable and depends on epitope expression.
Sign Up to like & getrecommendations! Published in 2018 at "Human immunology"
DOI: 10.1016/j.humimm.2017.10.019
Abstract: Virus-specific T cells can recognize allogeneic HLA (allo-HLA) through cross-reactivity of their T-cell receptor (TCR). In a transplantation setting, such allo-HLA cross-reactivity may contribute to harmful immune responses towards the allograft, provided that the cross-reactive… read more here.
Keywords: allo hla; cross; cross reactive; virus specific ... See more keywords
Generation of Zika virus-specific T cells from seropositive and virus-naïve donors for potential use as an autologous or "off-the-shelf" immunotherapeutic.
Sign Up to like & getrecommendations! Published in 2019 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2019.06.008
Abstract: BACKGROUND Zika virus (ZIKV) infection can cause severe birth defects in newborns with no effective currently available treatment. Adoptive transfer of virus-specific T cells has proven to be safe and effective for the prevention or… read more here.
Keywords: specific cells; zikv; shelf; virus specific ... See more keywords
Outcomes and Challenges of Manufacturing Virus-Specific Cytotoxic T-lymphocytes Using IFN-gamma Cytokine Capture System
Sign Up to like & getrecommendations! Published in 2020 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2020.03.092
Abstract: Background & Aim Background Viral infection/reactivation after allogeneic hematopoietic stem cell (HSCT) or solid organ transplant (SOT) is a significant cause of morbidity and mortality in drug-refractory patients. Adoptive transfer of allogeneic virus-specific cytotoxic T… read more here.
Keywords: specific cytotoxic; using ifn; ifn gamma; virus specific ... See more keywords
Cytomegalovirus and other herpesviruses after hematopoietic cell and solid organ transplantation: From antiviral drugs to virus-specific T cells.
Sign Up to like & getrecommendations! Published in 2022 at "Transplant immunology"
DOI: 10.1016/j.trim.2022.101539
Abstract: Herpesviruses can either cause primary infection or may get reactivated after both hematopoietic cell and solid organ transplantations. In general, viral infections increase post-transplant morbidity and mortality. Prophylactic, preemptive, or therapeutically administered antiviral drugs may… read more here.
Keywords: antiviral drugs; solid organ; virus specific; specific cells ... See more keywords
Therapeutic advantages provided by banked virus-specific T-cells of defined HLA-restriction
Sign Up to like & getrecommendations! Published in 2019 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-019-0614-1
Abstract: We have developed banks of EBV and CMV-specific T-cell lines generated from healthy seropositive third party donors and characterized them as to their HLA type, virus specificity, lack of alloreactivity, and HLA restriction. We here… read more here.
Keywords: specific cells; third party; therapeutic advantages; virus specific ... See more keywords
Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24608-5
Abstract: Latent human cytomegalovirus (HCMV) infection is characterized by limited gene expression, making latent HCMV infections refractory to current treatments targeting viral replication. However, reactivation of latent HCMV in immunosuppressed solid organ and stem cell transplant… read more here.
Keywords: human cytomegalovirus; virus specific; cell; virus ... See more keywords
Applications of virus-specific T cell therapies post-BMT.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2022.12.002
Abstract: Hematopoietic stem cell transplantation (HSCT) has been used as a curative standard of care for moderate to severe primary immunodeficiency disorders as well as relapsed hematologic malignancies for over 50 years [1,2]. However, chronic and… read more here.
Keywords: cell; applications virus; specific cell; therapies post ... See more keywords
A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116853118
Abstract: Significance By modeling in vitro the cross-talk between epithelial and immune cells, this work provides possible origins for the profound inflammatory perturbations that are a hallmark of COVID-19, and the relative protection of children from… read more here.
Keywords: response; monocyte inflammatory; sars cov; specific monocyte ... See more keywords
T Regulatory Cell Induced Foxp3 Binds the IL2, IFNγ, and TNFα Promoters in Virus-Specific CD8+ T Cells from Feline Immunodeficiency Virus Infected Cats.
Sign Up to like & getrecommendations! Published in 2018 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2017.0187
Abstract: Polyfunctional CD8+ T cells play a critical role in controlling viremia during AIDS lentiviral infections. However, for most HIV-infected individuals, virus-specific CD8+ T cells exhibit loss of polyfunctionality, including loss of IL2, TNFα, and IFNγ.… read more here.
Keywords: specific cd8; tnf; cd8; cd8 cells ... See more keywords
Continued Virus-Specific Antibody-Secreting Cell Production, Avidity Maturation and B Cell Evolution in Patients Hospitalized with COVID-19.
Sign Up to like & getrecommendations! Published in 2022 at "Viral immunology"
DOI: 10.1089/vim.2021.0191
Abstract: Understanding the development and sustainability of the virus-specific protective immune response to infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains incomplete with respect to the appearance and disappearance of virus-specific antibody-secreting cells (ASCs) in… read more here.
Keywords: cell; specific antibody; virus specific; igg ... See more keywords