Determinants of neurological syndromes caused by varicella zoster virus (VZV)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurovirology"
DOI: 10.1007/s13365-020-00857-w
Abstract: Varicella zoster virus (VZV) is a pathogenic human herpes virus which causes varicella as a primary infection, following which it becomes latent in peripheral autonomic, sensory, and cranial nerve ganglionic neurons from where it may… read more here.
Keywords: zoster virus; virus vzv; vzv; neurological syndromes ... See more keywords
Prodrug Strategies for the Development of β-l-5-((E)-2-Bromovinyl)-1-((2S,4S)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (l-BHDU) against Varicella Zoster Virus (VZV)
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.3c00545
Abstract: Varicella zoster virus (VZV) establishes lifelong infection after primary disease and can reactivate. Several drugs are approved to treat VZV diseases, but new antivirals with greater potency are needed. Previously, we identified β-l-5-((E)-2-bromovinyl)-1-((2S,4S)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (l-BHDU, 1),… read more here.
Keywords: zoster virus; bromovinyl hydroxymethyl; virus vzv; vzv ... See more keywords
FV-100 for the Treatment of Varicella-Virus (VZV) Infections: Quo Vadis?
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040770
Abstract: The bicyclic nucleoside analogue (BCNA) Cf1743 and its orally bioavailable prodrug FV-100 have unique potential as varicella-zoster virus (VZV) inhibitors to treat herpes zoster (shingles) and the therewith associated pain, including post-herpetic neuralgia (PHN). The… read more here.
Keywords: 100 treatment; virus vzv; vzv; treatment varicella ... See more keywords