A rapid pyrosequencing assay for the molecular detection of influenza viruses with reduced baloxavir susceptibility due to PA/I38X amino acid substitutions
Sign Up to like & getrecommendations! Published in 2020 at "Influenza and Other Respiratory Viruses"
DOI: 10.1111/irv.12725
Abstract: Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or highârisk individuals infected with influenza. Viruses with reduced baloxavir susceptibility due to amino acid substitutions at residue 38 of the PA… read more here.
Keywords: baloxavir susceptibility; viruses reduced; reduced baloxavir; influenza viruses ... See more keywords
Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009527
Abstract: Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patients. Treatment-emergent viruses with reduced susceptibility to baloxavir have been detected in clinical trials, but the likelihood of widespread… read more here.
Keywords: susceptibility; host fitness; ferret model; fitness ... See more keywords