The Role of Epigenomic Regulatory Pathways in the Gut-Brain Axis and Visceral Hyperalgesia.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01108-0
Abstract: The gut-brain axis (GBA) is broadly accepted to describe the bidirectional circuit that links the gastrointestinal tract with the central nervous system (CNS). Interest in the GBA has grown dramatically over past two decades along… read more here.
Keywords: visceral hyperalgesia; hyperalgesia; brain axis; epigenomic regulatory ... See more keywords
Downregulation of iNOS, IL-1β, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Immunology Research"
DOI: 10.1155/2018/3256908
Abstract: Protease-activated receptor 4 (PAR4) is implicated in the inhibition of visceral hyperalgesia. In the present study, the effects of PAR4 activation on visceral hypersensitivity and expression of inflammatory mediators, including interleukin-1β (IL-1β), P2RX7 purinergic receptor… read more here.
Keywords: par4; inos p2x7; visceral hyperalgesia; expression ... See more keywords
Rifaximin Improves Visceral Hyperalgesia via TRPV1 by Modulating Intestinal Flora in the Water Avoidance Stressed Rat
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology Research and Practice"
DOI: 10.1155/2020/4078681
Abstract: Background Rifaximin is effective in relieving pain symptoms with IBS patients, although the mechanisms were not clear. The aims of the research were to investigate whether the visceral hyperalgesia was alleviated by rifaximin via TRPV1… read more here.
Keywords: via trpv1; visceral hyperalgesia; rifaximin; intestinal flora ... See more keywords
NUCB2/Nesfatin-1 Regulation of Chronic Visceral Hyperalgesia
Sign Up to like & getrecommendations! Published in 2022 at "Applied Bionics and Biomechanics"
DOI: 10.1155/2022/4079533
Abstract: Objective We previously described that different concentration Nucleobindin-2 (NUCB2)/Nesfatin-1 gradients differently regulated visceral hypersensitivity in irritable bowel syndrome. Therefore, this study is aimed at evaluating the effect of NUCB2/Nesfatin-1 on model rats with chronic visceral… read more here.
Keywords: chronic visceral; visceral hyperalgesia; group; intervention ... See more keywords
A rat model for studying electroacupuncture analgesia on acute visceral hyperalgesia
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Animals"
DOI: 10.1538/expanim.17-0063
Abstract: The aim of this study was to establish an appropriate rat model to study the effect of electroacupuncture (EA) analgesia on acute visceral hyperalgesia. Adult rats received colorectal instillation with different concentrations of acetic acid… read more here.
Keywords: electroacupuncture analgesia; visceral hyperalgesia; hyperalgesia; acute visceral ... See more keywords
Elevated Levels of PGE2-Metabolite in Cerebrospinal Fluid and Cox-2 Gene Polymorphisms in Patients with Chronic, Post Cholecystectomy Pain and Visceral Hyperalgesia Compared to Healthy Controls. A Hypothesis-Generating Pilot Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pain Research"
DOI: 10.2147/jpr.s387502
Abstract: Purpose Chronic, abdominal pain remains a problem in a subset of patients after cholecystectomy. The cause is often obscure but central sensitization may be an important component and could theoretically be mediated by spinal PGE2,… read more here.
Keywords: cox; visceral hyperalgesia; post cholecystectomy; pain ... See more keywords