Decreased miR-325-5p Contributes to Visceral Hypersensitivity Through Post-transcriptional Upregulation of CCL2 in Rat Dorsal Root Ganglia
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-019-00372-x
Abstract: Chronic visceral hypersensitivity is an important type of chronic pain with unknown etiology and pathophysiology. Recent studies have shown that epigenetic regulation plays an important role in the development of chronic pain conditions. However, the… read more here.
Keywords: mirna 325; root ganglia; visceral hypersensitivity; ccl2 ... See more keywords
Protective effect of HCN2-induced SON sensitization on chronic visceral hypersensitivity in neonatal-CRD rat model
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2021.147538
Abstract: Abnormal brain-gut interactions contribute to the development of chronic visceral hypersensitivity (CVH), which is the pivotal feature of irritable bowel syndrome (IBS). Despite the consensus with respect to the vital role of hyperpolarization-activated cyclic nucleotide-gated… read more here.
Keywords: crd; visceral hypersensitivity; chronic visceral; rat model ... See more keywords
Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49096-y
Abstract: Irritable bowel syndrome (IBS) is a heterogenic, functional gastrointestinal disorder of the gut-brain axis characterized by altered bowel habit and abdominal pain. Preclinical and clinical results suggested that, in part of these patients, pain may… read more here.
Keywords: irritable bowel; visceral hypersensitivity; bowel syndrome; miltefosine ... See more keywords
The interaction between obesity and visceral hypersensitivity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16083
Abstract: Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome.… read more here.
Keywords: obesity visceral; visceral hypersensitivity; interaction obesity; obesity ... See more keywords
Neuroactive changes in the bowel of patients with IBS on low FODMAP diet: another piece of the puzzle
Sign Up to like & getrecommendations! Published in 2023 at "Gut"
DOI: 10.1136/gutjnl-2022-329184
Abstract: The publication of Rome IV saw the introduction of the term ‘disorder of gut brain interaction’ as a replacement for the previously used terminology ‘functional gastrointestinal (GI) disorder’ to describe GI conditions classified by symptoms… read more here.
Keywords: visceral hypersensitivity; fodmap diet; histamine; low fodmap ... See more keywords
Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/3860743
Abstract: Aim To investigate the effect of fecal microbiota transplantation on visceral hypersensitivity compared with Bifidobacterium longum. Methods Mice visceral hypersensitivity was induced by Trichinella spiralis. After 8 weeks, they were divided into three groups (controls,… read more here.
Keywords: visceral hypersensitivity; microbiota; microbiota transplantation; fecal microbiota ... See more keywords
P2X3 Receptor in Primary Afferent Neurons Mediates the Relief of Visceral Hypersensitivity by Electroacupuncture in an Irritable Bowel Syndrome Rat Model
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology Research and Practice"
DOI: 10.1155/2020/8186106
Abstract: Background Electroacupuncture (EA) has been confirmed effectiveness in the treatment of irritable bowel syndrome (IBS), and P2X3 receptors in the peripheral and central neurons participate in the acupuncture-mediated relief of the visceral pain in IBS.… read more here.
Keywords: receptor; rat model; visceral hypersensitivity; p2x3 receptor ... See more keywords
Progress on the Mechanism of Visceral Hypersensitivity in Nonerosive Reflux Disease
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology Research and Practice"
DOI: 10.1155/2022/4785077
Abstract: Nonerosive reflux disease (NERD) is the most common type of gastroesophageal reflux disease (GERD). Its clinical symptoms can recur, and clinical treatment is often ineffective, causing patients severe economic and psychological burden. In recent years,… read more here.
Keywords: reflux disease; nonerosive reflux; reflux; visceral hypersensitivity ... See more keywords
Sacral nerve stimulation with optimized parameters improves visceral hypersensitivity in rats mediated via the autonomic pathway
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Pain"
DOI: 10.1177/1744806919880651
Abstract: The purpose of this study was to determine effects and mechanisms of sacral nerve stimulation (SNS) on visceral hypersensitivity in rodent models of colonic hypersensitivity. SNS was performed with different sets of parameters for 30 min… read more here.
Keywords: stimulation; optimized parameters; visceral hypersensitivity; hypersensitivity ... See more keywords
Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pain"
DOI: 10.1177/17448069221144540
Abstract: Background: Accumulating evidence shows that N6-methyladenosine (m6A) modulators contribute to the process of chronic pain. However, the exact mechanisms of m6A writers involved in visceral hypersensitivity of Irritable bowel syndrome (IBS) remain unclear. This article… read more here.
Keywords: visceral hypersensitivity; nuclear export; regulating nuclear; hypersensitivity ... See more keywords
Circadian dysregulation induces alterations of visceral sensitivity and the gut microbiota in Light/Dark phase shift mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.935919
Abstract: Background It is well-established that several features of modern lifestyles, such as shift work, jet lag, and using electronics at night, disturb normal circadian rhythm and increase the risk of suffering from functional gastrointestinal disease.… read more here.
Keywords: dark phase; phase shift; visceral hypersensitivity; light dark ... See more keywords